Evidence map›Paper›PMID 42394962›Full record

ArticleClinical neurophysiology practice2026

Decremental responses following repetitive nerve stimulation in spinal and bulbar muscular atrophy.

Keisuke Tachiyama, Masahiro Nakamori, Yuki Fujii, Keiichi Hokkoku, Dai Agari, Shoji Hemmi, Eiichi Nomura, Yuki Hatanaka, Katsumi Kurokawa, Masahiro Sonoo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keisuke TachiyamaDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.
Masahiro NakamoriDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.
Yuki FujiiDepartment of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Keiichi HokkokuDepartment of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Dai AgariDepartment of Neurology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Shoji HemmiDepartment of Neurology, Kawasaki Medical School, Kurashiki, Japan.
Eiichi NomuraDepartment of Neurology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Yuki HatanakaDepartment of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Katsumi KurokawaDepartment of General Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
Masahiro SonooDepartment of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Hirofumi MaruyamaDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The presence of decremental responses following repetitive nerve stimulation (RNS) in amyotrophic lateral sclerosis (ALS) is well established. However, in spinal and bulbar muscular atrophy (SBMA), a rare X-linked recessive lower motor neuron disease, the incidence and distribution of decremental responses across different muscles have not been thoroughly investigated. Methods: Patients with SBMA were retrospectively identified in our database. RNS at a frequency of 3 Hz was performed on five muscles: the abductor pollicis brevis (APB), abductor digiti minimi (ADM), upper trapezius, deltoid, and facial muscles (frontalis or nasalis). Results: A total of forty patients were identified. A significant (> 5%) decremental response in at least one muscle was observed in all patients. It was observed more frequently in proximal muscles than in distal muscles: deltoid (86%), trapezius (70%), facial muscles (44%), APB (37%) and ADM (25%). The magnitude of the decremental response in the deltoid was significantly higher than that in the other muscles. Conclusions: Our results demonstrated that decremental responses were frequently observed in patients with SBMA, with a distribution pattern similar to that in ALS. The fact that the decremental responses are observed in SBMA having an extremely chronic course would be relevant for the pathophysiological mechanism of the decremental response. Significance: The RNS findings provide valuable insights into the pathological mechanisms of SBMA and may contribute to the development of future treatments.

Indexed as

Decremental responseRepetitive nerve stimulationSpinal and bulbar muscular atrophy

Identifiers

PMID42394962
PMCPMC13325735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.