Evidence map›Paper›PMID 42394954›Full record

ArticleBiomedical signal processing and control2026

A robust deep learning framework for automated fetal behavioral state classification: leveraging multi-center datasets to improve antepartum heart rate monitoring.

Giulio Steyde, Isabelle Mueller, Margaret C Shair, Edoardo Spairani, Luca Subitoni, Marta Campanile, Giovanni Magenes, William P Fifer, Nicolò Pini, Maria G Signorini

Abstract read
In one paragraph

Article in Biomedical signal processing and control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giulio SteydeDepartment of Electronics, Information and Bioengineering, Politecnico di Milano 20133 Milano, Italy.ORCID 0000-0002-2078-6173
Isabelle MuellerDepartment of Psychiatry, Columbia University Irving Medical Center, New York 10032, USA.ORCID 0000-0001-7511-6647
Margaret C ShairDepartment of Psychiatry, Columbia University Irving Medical Center, New York 10032, USA.
Edoardo SpairaniDepartment of Electrical, Computer and Biomedical Engineering, Università di Pavia 27100 Pavia, Italy.
Luca SubitoniDepartment of Electronics, Information and Bioengineering, Politecnico di Milano 20133 Milano, Italy.
Marta CampanileDepartment of Obstetrical-Gynecological and Urological Science, Federico II University, Napoli, Italy.
Giovanni MagenesDepartment of Electrical, Computer and Biomedical Engineering, Università di Pavia 27100 Pavia, Italy.ORCID 0000-0002-7558-1490
William P FiferDepartment of Psychiatry, Columbia University Irving Medical Center, New York 10032, USA.
Nicolò PiniDepartment of Psychiatry, Columbia University Irving Medical Center, New York 10032, USA.ORCID 0000-0002-0839-6033
Maria G SignoriniDepartment of Electronics, Information and Bioengineering, Politecnico di Milano 20133 Milano, Italy.

Funding

Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD055155 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIFER, WILLIAM P., MYERS, MICHAEL MORGAN · 2006 to 2015
$7.1M
Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS FunctionR01AA029159 · NIAAA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI FIFER, WILLIAM P. · 2022 to 2024
$1.3M
Continuous Glucose and Fetal State Monitoring: A Novel Approach to Understanding Neurodevelopmental Trajectories in Gestational DiabetesK99HD119289 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ISABELLE MUELLER · 2025 to 2026
$265k
NIAAA NIH HHS R01 AA029159NICHD NIH HHS K99 HD119289NICHD NIH HHS U01 HD055155
6 · The paper itself

Abstract

Fetal behavioral states reflect the developing brain's capacity to organize behavior into distinct sleep state patterns and are a window to evaluate the maturation of the nervous system throughout gestation. This study presents a deep learning-based methodology for the identification of behavioral states from fetal heart rate traces (FHR) recorded via cardiotocography (CTG). A Residual Attention U-Net was pre-trained on a large unlabeled dataset of over 7000 FHR recordings and fine-tuned on a multi-center dataset comprising 236 FHR signals with labeled states. These signals were collected across multiple countries using different cardiotocographs and annotated by clinicians with diverse backgrounds. The model showed high agreement with expert clinicians on a stratified hold-out test set, averaging a Macro F1-Score of 91% and Balanced Accuracy of 93% in distinguishing between

Indexed as

Behavioral statesCardiotocographyElectronic fetal monitoringSignal segmentation

Identifiers

PMID42394954
PMCPMC13327723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.