ArticleNature electronics2025
A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.
Article in Nature electronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Multifunctional material platforms for neural interfaces: active orchestration of dynamic foreign body response across implantation lifetimes.Bioactive materials · 2026Review
- A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals.Nature methods · 2026Article
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- A freestanding submicron electrocorticography electrode array.Nature communications · 2026Article
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- In Vivo Continuous Biosensing: Design Considerations and Emerging Technologies.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- HIPPIE: a generative model for electrophysiological analysis across species, technologies, and modalities.Nature communications · 2026Article
- High-channel-count neural recording and stimulation platform with 5376 simultaneous recording channels.npj biomedical innovations · 2026Article
- Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.Advanced healthcare materials · 2026Article
- Distributed Wireless Neural Recording System for Multi-Region Brain Activity Monitoring.Biosensors · 2026Article
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Closed-crown packaging system for stable, long-term neural recording in group-housed mice.Microsystems & nanoengineering · 2026Article
- High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels.bioRxiv : the preprint server for biology · 2026Article
- A modular, high-bandwidth, bidirectional implantable device for neural interrogation.bioRxiv : the preprint server for biology · 2026Article
- A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.Nature electronics · 2025Article
- Selective activation of mesoscale functional circuits via multichannel infrared stimulation of cortical columns in ultra-high-field 7T MRI.Cell reports methods · 2025Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.Current biology : CB · 2024Article
Corrections and comments
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Authors and funding
41 authors.
Funding
Abstract
Electrocorticography uses non-penetrating electrodes embedded in flexible substrates to record electrical activity from the surface of the brain. To use the technology to develop minimally invasive, high-bandwidth brain-computer interfaces, it will be necessary to improve the number of recording channels and the scalability of devices, which could be achieved by merging electrodes and electronics onto a single substrate. Here we report a 50-μm-thick, mechanically flexible micro-electrocorticography brain-computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal-oxide-semiconductor substrate. The device contains 65,536 recording electrodes, from which we can simultaneously record a selectable subset of up to 1,024 channels at a given time. Our chip is wirelessly powered, and when implanted below the dura, it can communicate bidirectionally with an external relay station outside the body. We show that the device can provide chronic, reliable recordings for up to two weeks in pigs and up to two months in behaving non-human primates from the somatosensory, motor and visual cortices, decoding brain signals at high spatiotemporal resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.