Evidence map›Paper›PMID 42394941›Full record

ArticleOrganic chemistry frontiers : an international journal of organic chemistry2026

Clarifying Stereochemical Outcomes in Radical-Initiated Vinyl Cyclopropane Cycloadditions within the Beckwith-Houk Framework.

Caitlyn O Agee, Het Vyas, Brandon S Portela, Amreen K Bains, Kun-Long Song, Maurice Médebielle, Robert S Paton, Abhishek Sharma, Jérémy Merad, Garret M Miyake and 1 more

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In one paragraph

Article in Organic chemistry frontiers : an international journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caitlyn O AgeeDepartment of Chemistry and Biochemistry, UNC Wilmington, Wilmington, NC, USA.
Het VyasDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Brandon S PortelaDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
Amreen K BainsDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
Kun-Long SongUniversite Claude Bernard Lyon 1, CNRS, INSA, CPE-Lyon, ICBMS UMR 5246, Villeurbanne F-69100 (France).
Maurice MédebielleUniversite Claude Bernard Lyon 1, CNRS, INSA, CPE-Lyon, ICBMS UMR 5246, Villeurbanne F-69100 (France).
Robert S PatonDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
Abhishek SharmaDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Jérémy MeradUniversite Claude Bernard Lyon 1, CNRS, INSA, CPE-Lyon, ICBMS UMR 5246, Villeurbanne F-69100 (France).
Garret M MiyakeDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
R Thomas WilliamsonDepartment of Chemistry and Biochemistry, UNC Wilmington, Wilmington, NC, USA.

Funding

Novel Acylborons and Alpha-hydroxy Borons to Enable Modular, Regio- and Stereocontrolled Synthesis of Bioactive Molecules and Protein ConjugatesR35GM143091 · NIGMS · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI SHARMA, ABHISHEK · 2021 to 2025
$1.5M
Modular Approaches to Unusual Borylated Heterocycles using Novel Acylborons and alpha-Hydroxy borons as Enabling ToolsR15GM135891 · NIGMS · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI SHARMA, ABHISHEK · 2020 to 2020
$463k
NIGMS NIH HHS R15 GM135891NIGMS NIH HHS R35 GM143091
6 · The paper itself

Abstract

The (3+2) cycloaddition reaction is a widely utilized strategy in organic synthesis for constructing cyclopentane frameworks, a structural motif prevalent in many bioactive compounds and pharmaceutical applications. Over the past decades, numerous catalytic radical cascade reactions orchestrated by various types of open-shell catalysts have been reported. However, discrepancies in the relative configurations of cyclopentanes obtained using closely related methodologies suggest that some stereochemical misassignments may have occurred. In this work, discrepancies in some of the originally assigned

Identifiers

PMID42394941
PMCPMC13327680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.