Trial reportFrontiers in neurology
Differential cortical responses of robot-assisted active and mirror therapy task conditions in stroke patients and healthy controls: a comparative fNIRS study.
Trial report in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Robot-assisted task conditions incorporating Active Movement Mode (AMM) and Mirror Therapy Mode (MTM) is widely used for upper-limb stroke rehabilitation. However, their differential task-related cortical responses remain insufficiently characterized. Objective: This study aimed to use functional near-infrared spectroscopy (fNIRS) to characterize and compare the task-dependent cortical activation and rest state functional connectivity profiles elicited by AMM and MTM in stroke patients and healthy controls. Methods: Twenty-three chronic stroke patients and twenty-three matched healthy controls performed robot-assisted upper limb tasks in both AMM and MTM. Cortical activation (Beta value) in the prefrontal (PFC), primary motor (M1), supplementary motor (SMA), premotor (PMC), and primary somatosensory (PSC) cortices was measured using a 48-channel fNIRS system. A Two-way repeated measures ANOVA to compare cortical activation; Hemispheric activation distribution was assessed by calculating the lateralization index (LI). To evaluate brain-behavior relationships, we used Pearson or Spearman correlation analyses to examine the association between ROI activation levels and FMA-UE scores. Furthermore, resting-state functional connectivity (RSFC) was compared between eyes-open and eyes-closed conditions. All multiple comparisons were corrected using the Benjamini-Hochberg FDR method. Results: Both groups showed extensive cortical activation across both modes ( Conclusion: Active Movement Mode and Mirror Therapy Mode exhibited distinct cortical activation and functional connectivity profiles during robot-assisted upper-limb tasks. Compared with MTM, AMM was associated with stronger recruitment of several motor-related regions, while differences in connectivity further supported distinct modes of neural engagement. Clinical trial registration: Unique identifier: ChiCTR2500096992, URL: https://www.chictr.org.cn.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.