ArticleBioengineering & translational medicine2026
Dynamic pillar-perfusion platform for screening enzyme-induced self-assembling peptide therapeutics in 3D breast cancer spheroids.
Article in Bioengineering & translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Enzyme-induced self-assembling peptides (EISAPs) are a promising class of enzyme-activated anticancer therapeutics, yet their translational screening is limited by the lack of 3D tumor models that effectively capture drug penetration, self-assembly dynamics, and treatment response. To address this need, we developed a pillar-perfusion 3D breast cancer spheroid platform to screen a six-peptide panel-P1 (Fmoc-FF-pTyr), P2 (Fmoc-FF-pThr), P3 (RGD-FF-pTyr), P4 (NBD-FF-pTyr), P5 (Nap-FF-pTyr), and P6 (Nap-FF-pThr)-under static and dynamic flow. Hydrogel optimization identified a 2% gelatin/1% alginate matrix enabling
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