ArticleFrontiers in physiology2026
A pilot longitudinal spectral CT study of fructose-related bone microstructure in rats: exploring technical advantages.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Assessing the unique advantages of spectral CT as a real-time, dynamic, and Methods: Eighteen 3-week-old male Sprague-Dawley rats were randomized into experimental (standard chow + 25% fructose water, n=9) and control groups (standard chow + sterile water, n=9) for 8 weeks. Spectral CT scans were performed at weeks 0, 4, and 8. Calcium (Water) [Ca(Water)], Phosphorus (Water) [P(Water)], and Hydroxyapatite (Water) [HAP(Water)] values of the left femur were measured, and their rates of change were calculated. After 8 weeks, left femurs were harvested for distal femur histology. HE staining assessed trabecular parameters: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N). Inter-group comparisons of trabecular parameters, intra- and inter-group comparisons of spectral parameters and their change rates, and correlation analyses between trabecular and spectral parameters were conducted. Results: At week 8, the experimental group showed significantly higher BV/TV, Tb.Th, and Tb.N, but no difference in Tb.Sp versus controls. Spectral CT parameters were significantly elevated in the experimental group only at week 8. In both groups, parameters at weeks 4 and 8 exceeded baseline, and week 8 values exceeded week 4 values. The rates of change from 4 to 8 weeks (rate of change Conclusion: Spectral CT, as a real-time, dynamic, and
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