ArticleFrontiers in bioengineering and biotechnology2026
Development of a fast-crosslinking hydrogel system doped with magnetic mesoporous nanoparticles for sustained fluoride ion release and caries prevention.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Maintaining therapeutic fluoride ion concentrations is essential for preventing enamel demineralization and treating dental defects. However, achieving localized retention and sustained release in the dynamic oral environment remains a significant challenge. Aims: To develop a multifunctional fluoride ion delivery platform to bridge the gap between high-capacity ion loading and clinical stability at the target site. Methods: We engineered a hybrid delivery system by integrating fluoride adsorbing magnetic mesoporous nanoparticles (FSMNs) into an ultra-fast photocrosslinkable hyaluronic acid hydrogel matrix (HFMM/PEG). The HFMM polymer, featuring both methacrylic acid and norbornene groups, was synthesized to facilitate rapid Results: The HFMM/PEG/FSMN-F Conclusion: This hybrid hydrogel system bridged the gap between high-capacity ion loading and clinical retention, offering a promising strategy for the long-term prevention of white spot lesions (early caries) in orthodontic and restorative dentistry.
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