Efficacy and Safety of Microneedling Combined With Mesotherapy for Androgenic Alopecia: A Retrospective Study Comparing Four Treatment Protocols.

Background and Aims: Androgenic alopecia (AGA) is a prevalent form of hair loss characterized by progressive miniaturization of hair follicles, significantly impacting patients' self-confidence and quality of life. Current FDA-approved treatments demonstrate limited to moderate efficacy. Microneedling combined with mesotherapy techniques has emerged as a promising drug delivery system for enhancing therapeutic outcomes in hair loss disorders. This retrospective interventional study aimed to evaluate the efficacy and safety of four distinct microneedling-based mesotherapy protocols for the treatment of androgenic alopecia. Methods: Sixty-three patients with clinically confirmed AGA were allocated to four treatment groups. All groups received microneedling therapy combined with different mesotherapy formulations: Group I ( Results: Thirty-nine women and 24 men completed the study. Women demonstrated significantly higher improvement rates (48%) compared to men (29%). Female pattern hair loss showed better response (45%) than male pattern AGA (37.5%). Participants under 30 years achieved higher improvement rates (47%) compared to those aged 30-49 years (42.9%). Group IV (combination therapy with finasteride and latanoprost) demonstrated the highest efficacy across both sexes and hair loss patterns. All treatment protocols were well-tolerated with minimal adverse effects. Conclusions: The findings of the current study support the use of combination mesotherapy protocols for enhanced therapeutic outcomes in AGA management.