Mutation profile and therapeutic implications in Peutz-Jeghers syndrome-associated gastric-type endocervical adenocarcinoma.

Tianhui Niu, Xiaofang Liu, Siqi Zhang, Mengnan Yu, Xiaoying Wang, Jinghui Jia

Abstract read

In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianhui Niu *Department of Obstetrics, Gynecology and Reproductive Sciences, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Xiaofang Liu *Department of Obstetrics, Gynecology and Reproductive Sciences, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Siqi ZhangDepartment of Obstetrics, Gynecology and Reproductive Sciences, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Mengnan YuDepartment of Ultrasound, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Xiaoying WangLaboratory of clinical medicine, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Jinghui JiaDepartment of Obstetrics, Gynecology and Reproductive Sciences, Air Force Medical University, Air Force Medical Center, People's Liberation Army, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric-type endocervical adenocarcinoma (G-EAC) is a rare, highly aggressive malignancy that is not associated with human papillomavirus (HPV) infection. Its occurrence in patients with Peutz-Jeghers syndrome (PJS) is exceptionally rare but clinically critical. In this preliminary study, we performed comprehensive genomic profiling (CGP) using a targeted next-generation sequencing (NGS) panel and immunohistochemistry (IHC) for key biomarkers on a single, well-characterized patient with stage IB3 PJS-associated G-EAC. The primary objective was to identify actionable genomic alterations and potential therapeutic targets to inform personalized treatment strategies. CGP revealed a pathogenic germline

Indexed as

Claudin 18.2ERBB3gastric-type endocervical adenocarcinomamolecular profilingPeutz-Jeghers syndromeprecision oncologytargeted therapy

Identifiers

PMID42394698

DOI10.3389/fonc.2026.1780688

PMCPMC13323026

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.