ArticleEuropean heart journal. Imaging methods and practice2026
Cardiac remodelling and clinical outcomes after mitral edge-to-edge repair with the PASCAL® system.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comments on 'Cardiac remodelling and clinical outcomes after mitral edge-to-edge repair with the PASCAL® system'.European heart journal. Imaging methods and practice · 2026Article
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Authors and funding
18 authors.
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Abstract
Aims: Chronic mitral regurgitation (MR) causes haemodynamic and myocardial changes leading to increased left atrial volume and left ventricular preload and finally eccentric hypertrophy of the left ventricle. The extent to which mitral valve transcatheter edge-to-edge repair induced haemodynamic improvements translates into reverse remodelling and clinical benefit remains to be clarified. This project aimed to investigate periprocedural haemodynamic changes during mitral valve transcatheter edge-to-edge repair, their effects on reverse cardiac remodelling, and the associated effects on heart failure-related hospitalization and all-cause mortality. Methods and results: In this retrospective study, 130 patients with severe symptomatic MR underwent transcatheter edge-to-edge repair. Haemodynamic parameters were assessed pre- and immediately post-procedure, and echocardiography was performed at 6-12 months (median 188 days, IQR 26). Clinical follow-up included 1-year heart failure hospitalization and all-cause mortality. Short-term haemodynamic data were available in 86 patients and long-term echocardiographic follow-up in 73, with incomplete datasets excluded from the respective analyses. Mitral valve transcatheter edge-to-edge repair significantly improved cardiac index (+11.37%, Conclusion: Mitral valve transcatheter edge-to-edge repair with the PASCAL® system is linked with immediate haemodynamic improvements that may be associated with reverse cardiac remodelling and improved mid-term clinical outcomes. Monitoring acute haemodynamic effects may help predict positive remodelling and outcome effects.
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