ArticleMolecular ecology2026
Differential Immune Responses Correlate With Chytridiomycosis Severity in Italian Crested Newts.
Article in Molecular ecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Differential Immune Responses Correlate With Chytridiomycosis Severity in Italian Crested Newts.Molecular ecology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
In the midst of the current biodiversity crisis, amphibians are severely threatened by emerging diseases such as chytridiomycosis. Characterizing the mechanisms that underlie susceptibility to this disease is fundamental to improve amphibian conservation. Using a comprehensive multi-omics approach, this study investigates the impact of an exposure to the chytrid fungus Batrachochytrium salamandrivorans (Bsal) on the gene expression of Italian crested newts (Triturus carnifex) and on the bacterial symbionts that constitute their skin microbiota. Exposure to Bsal affected multiple components of the newts' immunity, from limited structural changes in their microbiota and decreased expression of keratin-encoding genes in the skin to the upregulation of genes involved in inflammation and adaptive immunity both at the site of infection (skin) and in their primary lymphoid organ (spleen). We found that chytridiomycosis severity was positively correlated with the downregulation of basal metabolism and with the upregulation of immune responses and of tissue restructuration. Together, our results suggest that in T. carnifex, Bsal susceptibility may be linked to a reallocation of energy resources from the maintenance of basal metabolism and tissue integrity towards elevated immunity and tissue restructuration.
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