Evidence map›Paper›PMID 42394370›Full record

ArticleTransboundary and emerging diseases2026

Isolation and Characterization of a Highly Virulent Getah Virus Causing Acute Lethal Infection in Neonatal Piglets.

Zhengxin Yang, Weidong Yan, Xuefei Wang, Mengjia Zhang, Zongyang Peng, Mengdi Zhang, Ahmed H Ghonaim, Xuexiang Yu, Thi Trang Vy, Xugang Ku and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhengxin YangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.ORCID https://orcid.org/0000-0001-5832-9253
Weidong YanNational Key Laboratory of Agricultural Microbiology and Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Xuefei WangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Mengjia ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Zongyang PengCollege of Informatics, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Mengdi ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Ahmed H GhonaimCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Xuexiang YuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Thi Trang VyCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Xugang KuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.
Mingguang ZhouWuhan Keqian Biology Co. Ltd., Wuhan, 430072, China.
Gaoyuan XuWuhan Keqian Biology Co. Ltd., Wuhan, 430072, China.
Anan JongkaewwattanaVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand, nstda.or.th.
Qigai HeCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.ORCID https://orcid.org/0000-0001-7005-7473
Wentao LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, hzau.edu.cn.ORCID https://orcid.org/0000-0002-7114-762X

Funding

China Agriculture Research System of MOF and MARA CARS-35Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China JYB2025XDXM704Huazhong Agricultural University 2025HZAUHNZS001Innovation Fund of International Joint Research Center of National Animal Immunology 2025IJRCNAI09Key Research and Development Program of Jiangxi Province 20261BCF320004National Key Research and Development Program of China 2025YFC3507700Yingzi Tech & Huazhong Agricultural University Intelligent Research Institute of Food Health IRIFH202209
6 · The paper itself

Abstract

Getah virus (GETV) is a mosquito-borne alphavirus with an expanding host range and an increasing impact on swine production, particularly in neonatal piglets. In this study, a severe disease outbreak characterized by acute diarrhea and high mortality occurred among suckling piglets on a commercial pig farm in central China. Comprehensive pathogen screening excluded common bacterial pathogens and major enteric viruses, whereas GETV RNA was consistently detected in multiple tissues. A GETV strain, designated GETV-WH, was successfully isolated from lung tissue and propagated in BHK-21 cells, where it reproducibly induced pronounced cytopathic effects (CPEs). The isolate was confirmed by immunofluorescence assay (IFA) using a GETV E2-specific monoclonal antibody and further purified by plaque assays. Growth kinetics analysis demonstrated efficient viral replication, with peak titers exceeding 10

Indexed as

AlphavirusAlphavirus InfectionsSwine DiseasesAnimal HusbandryAnimalsAnimals, NewbornChinaDisease OutbreaksPhylogenySwineVirulenceGetah virusneonatal pigletsphylogenetic analysisswine diseaseviral virulencevirus isolation

Identifiers

PMID42394370
PMCPMC13329109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.