ArticleMuscle & nerve2026
Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.
Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
INTRODUCTION/
aimsCombined central and peripheral demyelination (CCPD) is a rare dysimmune disorder sharing features with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Direct comparisons of central and peripheral diagnostic findings across these entities remain limited. We, therefore, performed a systematic study assessing nervous system involvement in CCPD, using magnetic resonance imaging (MRI), nerve ultrasound (US), and nerve conduction study (NCS) and compared findings to MS and CIDP controls.
methodsWe conducted a descriptive case study including 4 CCPD patients, 13 CIDP patients, and 10 MS controls. All subjects underwent a standardized protocol of NCS and US. In addition, MS and CCPD patients also underwent brain and spinal cord MRI. Cerebrospinal fluid testing was performed in 20/27 patients.
resultsNCS revealed electrodiagnostic features suggestive of demyelination in all CCPD and CIDP patients, fulfilling the electrodiagnostic criteria for CIDP. We found motor conduction abnormalities in two MS patients, not fulfilling criteria for demyelination. US showed a similar pattern of multifocal nerve enlargement in CCPD and CIDP patients, while three MS patients also demonstrated mild proximal median nerve enlargement. Finally, CSF oligoclonal bands were only found in MS patients. DISCUSSION: Peripheral diagnostic tools reveal strikingly similar electrophysiological and morphologic features in CCPD and CIDP, underscoring a potential overlap in their disease mechanisms and the challenges of distinguishing these entities based on peripheral nerve assessment alone. Our findings further suggest that US could serve as a potentially useful screening tool in patients with predominantly central nervous system demyelinating syndromes and suspected peripheral involvement, helping to guide subsequent electrophysiological testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.