Evidence map›Paper›PMID 42394202›Full record

ArticleEuropean journal of clinical investigation2026

Pacemaker Status and 5-Year Mortality After TAVI: A Sex-Specific Analysis.

Cecilia Veraar, Gudrun Lamm, Maximilian Will, Matthias Hammerer, Matthias Granner, Lion Merl, Konstantin Schwarz, Julia Mascherbauer

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Article in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Cecilia VeraarDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.ORCID https://orcid.org/0000-0001-9378-5000
Gudrun LammDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
Maximilian WillDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
Matthias HammererDepartment of Internal Medicine II, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Matthias GrannerDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
Lion MerlDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
Konstantin SchwarzDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
Julia MascherbauerDepartment of Internal Medicine 3, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex-specific differences regarding the prognostic impact of permanent pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI) remain largely unexplored.

objectivesTo investigate sex-specific associations between pre-existing and new post-procedural PM implantation and short- and long-term mortality after TAVI.

methodsThis post hoc analysis of a prospective registry included consecutive patients who underwent TAVI between 2016 and 2020. Patients were stratified by sex and assigned to three groups: no PM, pre-existing PM (pre-PM) and PM implantation within 30 days of TAVI (post-PM). The primary endpoint was 5-year all-cause mortality; the secondary endpoint was 30-day mortality. Sex-stratified multivariable proportional hazards models and Kaplan-Meier analyses were performed.

resultsAmong 1114 patients (81 ± 5 years, 49.8% female), women more frequently had no PM (80.2% vs. 70.8%, p < 0.001) and less often had a pre-existing PM (7.0% vs. 14.5%, p < 0.001). Post-PM rates were similar between sexes (12.8% vs. 14.7%, p = 0.172). Thirty-day survival differed by PM status only in women, with worse outcomes in the post-PM group (log-rank p = 0.033), whereas no difference was observed in men (p = 0.542). Five-year survival did not differ by PM status among women (p = 0.572) but differed significantly among men (p < 0.001), with the lowest survival in men with pre-PM.

conclusionPost-procedural PM implantation was associated with higher 30-day mortality in women, whereas pre-existing PM predicted reduced 5-year survival in men, supporting sex-specific risk assessment before and after TAVI.

Indexed as

Aortic Valve StenosisPacemaker, ArtificialTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFemaleHumansKaplan-Meier EstimateMaleProportional Hazards ModelsProspective StudiesRegistriesRisk FactorsSex Factorsaortic stenosismortalitypacemakersex differencestranscatheter aortic valve implantation

Identifiers

PMID42394202
PMCPMC13329084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.