ArticleDiabetic medicine : a journal of the British Diabetic Association2026
Clinical characteristics and in-hospital mortality among insulin pump users with acute coronary syndrome in the predominantly open-loop era: A UK-wide MINAP registry analysis.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical characteristics and in-hospital mortality among insulin pump users with acute coronary syndrome in the predominantly open-loop era: A UK-wide MINAP registry analysis.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe compared characteristics of adults with insulin-treated diabetes using continuous subcutaneous insulin infusion (CSII) versus multiple daily insulin injections (MDI) during admission with acute coronary syndrome (ACS) and identified factors associated with in-hospital mortality among CSII users.
methodsThis retrospective cohort study used the Myocardial Ischaemia National Audit Project, a registry of ACS admissions in England and Wales. Adults aged ≥18 years with confirmed ACS and insulin-treated diabetes were classified as CSII or MDI users. Baseline characteristics were compared. Gradient boosting machine (GBM) modelling and multivariable logistic regression evaluated mortality predictors among CSII users.
resultsThe cohort included 3321 CSII users and 30,593 MDI users. In-hospital mortality was higher among CSII users (11.4% vs. 5.1%; p < 0.001). CSII users had higher rates of cardiogenic shock (4.8% vs. 1.3%), pulmonary oedema (12.1% vs. 8.3%), poor left ventricular systolic function (23.5% vs. 19.7%), and STEMI (32.2% vs. 20.5%). Cardiogenic shock was the strongest predictor of mortality (adjusted OR 10.46, 95% CI 6.95-15.81), followed by poor left ventricular function (OR 4.15, 95% CI 2.69-6.53), basal crepitations (OR 1.94, 95% CI 1.40-2.67) and pulmonary oedema (OR 1.56, 95% CI 1.05-2.28). Higher systolic blood pressure was associated with lower mortality (OR 0.86 per 10 mmHg, 95% CI 0.82-0.90). The GBM model achieved an AUC of 0.85 and a Brier score of 0.088.
conclusionsCSII users admitted with ACS represented a more complex group with haemodynamic compromise and higher unadjusted mortality. Findings predominantly reflect the open-loop CSII era and may not generalise to contemporary hybrid closed-loop systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.