Evidence map›Paper›PMID 42393826›Full record

ArticleGut microbes2026

Early risk stratification of late-onset sepsis in very preterm infants by intestinal microbiota profiling: a multicenter case-control validation study.

Nina M Frerichs, Rimke R de Kroon, Yannick van Schajik, Sofia El Manouni El Hassani, Aranka J van Wesemael, Willem P de Boode, Veerle Cossey, Christian V Hulzebos, Chris H P van den Akker, Marlou M A Raets and 13 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Nina M FrerichsDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-3568-863X
Rimke R de KroonDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-7971-3120
Yannick van SchajikAmsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0009-0000-0939-9722
Sofia El Manouni El HassaniDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-2806-444X
Aranka J van WesemaelDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0009-0007-6957-3850
Willem P de BoodeNeonatal Intensive Care Unit, Radboud University Medical Centre, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, the Netherlands.ORCID 0000-0003-3194-7005
Veerle CosseyNeonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0001-6900-1974
Christian V HulzebosNeonatal Intensive Care Unit, Beatrix Children's Hospital/University Medical Centre Groningen, Groningen, the Netherlands.ORCID 0000-0002-8159-7501
Chris H P van den AkkerAmsterdam Reproduction and Development Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0002-5494-730X
Marlou M A RaetsDivision of Neonatology, Maastricht University Medical Center+, MosaKids Children's Hospital, Maastricht, the Netherlands.ORCID 0000-0002-5534-7728
Esther J d'HaensNeonatal Intensive Care Unit, Amalia Children's Centre, Isala, Zwolle, the Netherlands.ORCID 0000-0002-3434-2696
Daniel VijlbriefNeonatal Intensive Care Unit, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-2682-7386
Mirjam M van WeissenbruchDepartment of Neonatology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0002-8086-9552
Wouter J de JongeTytgat Institute, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0002-3241-1547
Nanne K de BoerAmsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0001-8357-9887
Johannes B van GoudoeverAmsterdam Reproduction and Development Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0003-3960-1703
Andrew D BeggsDepartment of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-0784-2967
Mohammed Nabil QuraishiDepartment of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-2338-8397
Mark DavidsMicrobiota Center Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-3081-9124
Sudip MondalDepartment of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-7575-3849
Animesh AcharjeeDepartment of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-2735-7010
Hendrik J NiemarktNeonatal Intensive Care Unit, Máxima Medical Center, Veldhoven, the Netherlands.ORCID 0000-0002-0844-7208
Tim G J de MeijDepartment of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-7556-5896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal bacterial translocation to the bloodstream is a route of infection for late-onset sepsis (LOS) in preterm infants, highlighting the potential of fecal microbiota profiling for early risk stratification. We aimed to identify and validate LOS-specific gut microbiota signatures. Fifty-eight preterm infants (gestational age < 30 weeks) with blood culture-proven LOS (excluding coagulase-negative

Indexed as

BacteriaGastrointestinal MicrobiomeNeonatal SepsisSepsisCase-Control StudiesFecesFemaleHumansInfant, NewbornInfant, PrematureMaleRisk AssessmentRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNA gene sequencingbloodstream infectionGut microbiomeneonatal intensive care unitpremature neonatessepticemia

Identifiers

PMID42393826
PMCPMC13336302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.