ArticleBMC nutrition2026
The effects of a novel combination of a probiotic supplement (L. rhamnosus GG, L. acidophilus, and L. casei) with a weight gain intervention on body composition, appetite, gut permeability, oxidative stress, and inflammation in underweight adults: study protocol for a double-blind, randomized controlled trial.
Article in BMC nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
introductionUndernutrition, characterized by insufficient energy and protein intake and/or malabsorption, leads to adverse physical and mental health outcomes. Addressing Undernutrition is complex, requiring adequate dietary intake and consideration of the gut microbiota, which is crucial for nutrient absorption and metabolism. Probiotics have shown potential in restoring the gut microbiota balance, enhancing nutrient absorption, and improving growth and immune function. The proposed double-blind, randomized controlled trial (RCT) aims to evaluate the effects of a novel probiotic combination in conjunction with a weight gain intervention on body composition, appetite, gut permeability, oxidative stress, and inflammation in severely underweight adults.
methodsA double-blind, randomized controlled trial in which 100 underweight (BMI < 18.5 kg/m DISCUSSION: This study outlines a comprehensive approach to investigating the impact of probiotics in combination with dietary intervention on multiple health parameters in underweight adults. The results of this trial will contribute to further ways of managing malnutrition. ETHICS AND DISSEMINATION: This study was approved by the Ethics Committee of the Research Vice-Chancellor at Mashhad University of Medical Sciences (IR.MUMS.MEDICAL.REC.1401.589) (IR.MUMS.MEDICAL.REC.1402.057). All participants will be asked to complete the consent form at the beginning of the study. The results will be actively disseminated through peer-reviewed journals and conference presentations. TRIAL REGISTRATION {2A AND 2B}: Iranian Registry of Clinical Trials, IRCT20230310057667N1 (Issue date 30 March 2023), https://irct.behdasht.gov.ir/trial/69130 .
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