ArticleVirology journal2026
A yellow fever 17D and Usutu virus chimera with rationally designed mutations in the envelope protein is lethal in an Ifnar
Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The expanding geographical spread of Usutu virus (USUV) poses an increasing threat to bird populations and to human health. Here we assessed a chimeric USUV vaccine candidate that was constructed using the live attenuated yellow fever virus (YFV) YF-17D platform. In our chimeric virus, the pre-membrane (PrM) and envelope (E) proteins of YFV were replaced with those of USUV. Similar chimeras of YF-17D with otherflaviviruses have been reported to be attenuated in vivo, making them promising modified live virus vaccine candidates. We used either wild type USUV PrME or USUV PrME containing rationally designed mutations in the E protein that were expected to (further) attenuate the virus, based on their effect in the context of other orthoflaviviruses. In cell culture the YF-17D/USUV chimeric viruses displayed reduced fitness compared to both YF-17D and USUV, with the chimera containing the mutated USUV E exhibiting the slowest growth kinetics. However, in our interferon α/β receptor deficient (Ifnar
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