Evidence map›Paper›PMID 42393638›Full record

ArticleBMC surgery2026

A nomogram for predicting early- and mid-term native liver survival after surgery in patients with type III biliary atresia: a single-center retrospective study.

Sijin Li, Jixiao Zeng, Xiaogang Xu, Boyuan Tao, Zhihua Ye, Menglong Lan, Hong Zhang, Yuanyuan Luo, Zijian Liang, Zhizu Zhong and 3 more

Abstract read
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Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Sijin LiDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Jixiao ZengDepartment of Pediatric Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xiaogang XuDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Boyuan TaoDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhihua YeDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Menglong LanDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Hong ZhangDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Yuanyuan LuoDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zijian LiangDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhizu ZhongDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Lini WenDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Shuoshuo GuoDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Fei LiuDepartment of Pediatric Surgery, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. star5044207@163.com.

Funding

Guangzhou Clinical Characteristic Technology Project 2023C-TS48Guangzhou Municipal Health Science and Technology Project 20231A011040Municipality and University (Institute) Joint Funding Project of Guangzhou Science and Technology Plan 2024A03J1236National Natural Science Foundation of China 82170528Natural Science Foundation of Guangdong Province 2022A1515012254
6 · The paper itself

Abstract

backgroundBiliary atresia (BA) is a severe obstructive biliary disease. This study aimed to explore the independent risk factors influencing the prognosis of BA in children who underwent Kasai portoenterostomy (KPE) and to construct a nomogram for predicting the prognosis.

methodsThe clinical data of patients with type III BA who underwent KPE at Guangzhou Women and Children's Medical Center from June 2016 to May 2024 were retrospectively analyzed. Univariate and multivariate Cox regression analyses were used to screen for independent risk factors. A nomogram was constructed using the screened variables to predict postoperative early- and mid-term native liver survival (NLS). The predictive efficacy of the model was evaluated using the concordance index (C-index), receiver operating characteristic (ROC) curve and area under the curve (AUC), and calibration curves.

resultsTwo hundred patients with type III BA whose clinical data were available were randomly divided into training and validation cohorts at a ratio of 7:3. Age at surgery, recurrent cholangitis, early bile drainage (EBD), and aspartate aminotransferase (AST) level within 1 month after surgery were identified as independent risk factors (all P < 0.05), and a nomogram was constructed using these factors. The C-index was 0.76 (95% CI: 0.71, 0.80) for the training cohort and 0.69 (95% CI: 0.57, 0.75) for the validation cohort. Excellent discrimination and calibration were observed for both groups.

conclusionThe nomogram constructed using variables such as age at surgery, recurrent cholangitis, EBD, and postoperative AST level can accurately predict the probability of NLS after surgery, providing a quantifiable assessment tool for clinical individualized clinical management.

Indexed as

Biliary AtresiaNomogramsPortoenterostomy, HepaticFemaleHumansInfantMalePrognosisRetrospective StudiesRisk FactorsBiliary atresiaCholangitisJaundice clearanceKasai portoenterostomyNative liver survivalNomogram

Identifiers

PMID42393638
PMCPMC13599080

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