Trial reportBMC cancer2026
Beyond side effects: treatment-related adverse events are associated with improved survival outcomes in HCC patients on atezolizumab-bevacizumab therapy.
Trial report in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open-Label, Multicenter Phase Ib Study of The Safety and Efficacy of Atezolizumab (Anti-PD-L1 Antibody) Administered in Combination With Bevacizumab and/or Other Treatments in Patients With Solid Tumors
A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundAtezolizumab plus bevacizumab (Atez/Bev) is the first-line treatment for unresectable hepatocellular carcinoma (HCC). This study investigated the association of adverse events (AEs) with clinical outcomes by treatment relation, organ systems, and severity.
methodsThis exploratory post hoc analysis included 435 HCC patients treated with Atez/Bev, 136 patients with sorafenib, and 58 patients with atezolizumab monotherapy from the IMbrave150 (NCT03434379) and GO30140 (NCT02715531) trials. Kaplan-Meier analysis was applied to estimate overall survival (OS) in patients treated with Atez/Bev for ≥ 3 months.
resultsLandmark analysis at 3 months restricted the OS analysis to 332 patients who completed ≥ 3 months of Atez/Bev. Among these patients, treatment-related renal/urinary, mild vascular, and skin/subcutaneous AEs were associated with improved OS compared with patients without the corresponding AE (mOS: not reached vs. 20.2 months, p < 0.001; not reached vs. 20.2 months, p < 0.001; and not reached vs. 22.8 months, p = 0.014, respectively). Experiencing one (HR = 0.56, 95% CI: 0.38, 0.81) or ≥ 2 types (HR = 0.20, 95% CI: 0.11, 0.37) of positively associated AEs demonstrated progressively improved OS. However, metabolism/nutrition, hepatobiliary, and grade 3 + gastrointestinal AEs were associated with poorer OS, with HRs at 1.58 (95% CI: 1.10, 2.26), 1.67 (95% CI: 1.08, 2.69) and 2.09 (95% CI: 1.28, 3.41), respectively.
conclusionsAtez/Bev-related renal/urinary, skin/subcutaneous, and mild vascular AEs were associated with favorable survival outcomes in HCC, whereas metabolism/nutrition, hepatobiliary, and severe gastrointestinal AEs were associated with poorer outcomes. These findings may help improve the interpretation of AEs during Atez/Bev treatment and inform individualized toxicity management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.