Evidence map›Paper›PMID 42393538›Full record

ArticleBMC medical imaging2026

Gd-EOB-DTPA-enhanced MRI in the diagnosis of intrahepatic cholestasis in mice: an experimental study.

Siyu Wang, Rencai Lu, Mingkang Wu, Qing Li, Yinghong Zhang, Linxiu Liu, Yuqi Yang, Kunhua Wu, Shaobo Wang

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In one paragraph

Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Siyu Wang *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0002-2503-4640
Rencai Lu *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Mingkang WuDepartment of Nuclear Medicine, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, Yunnan, 650032, China.
Qing LiDepartment of MRI, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Yinghong ZhangDepartment of Pathology, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Linxiu LiuDepartment of Pathology, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Yuqi YangDepartment of Nuclear Medicine, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, Yunnan, 650032, China.
Kunhua WuDepartment of MRI, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Shaobo WangDepartment of Nuclear Medicine, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, Yunnan, 650032, China. wshbo_98@126.com.

Funding

Kunming University of Science and Technology Medical Joint Special Fund KUST-KH2023014YNational Natural Science Foundation of China 82260355Yunnan Provincial Science and Technology Department - Key R&D Program 202403AC100018Yunnan Provincial Science and Technology Department-Kunming Medical University Basic Research Joint Special Fund 202401AY070001-250
6 · The paper itself

Abstract

backgroundThe diagnosis of intrahepatic cholestasis remains challenging due to a lack of reliable noninvasive biomarkers. This study aimed to define the diagnostic utility of semi-quantitative parameters from Gd-EOB-DTPA-enhanced MRI for assessing pathological severity in a murine model of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced intrahepatic cholestasis.

methodsThirty female Kunming mice were divided into control (n = 5) and DDC-fed (n = 20) groups. Multi-timepoint (0-60 min post-injection) Gd-EOB-DTPA-enhanced MRI at 3.0T was performed to derive kinetic parameters-maximum relative enhancement (RE

resultsDDC feeding induced progressive cholestatic injury, evident on histology from week 2 onward. MRI revealed distinct kinetic impairments: attenuated hepatic RE

conclusionsGd-EOB-DTPA-enhanced MRI quantitatively captures functional impairment in mice intrahepatic cholestasis. Gallbladder excretion kinetics (Slope

Indexed as

Cholestasis, IntrahepaticContrast MediaGadolinium DTPAMagnetic Resonance ImagingAnimalsDisease Models, AnimalFemaleLiverMicePyridines3,5-diethoxycarbonyl-1,4-dihydrocollidineContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAPyridines3,5-diethoxycarbonyl-1,4-dihydrocollidineCholestasisGadolinium ethoxybenzyl diethylenetriaminepentaacetic acidMagnetic resonance imaging

Identifiers

PMID42393538
PMCPMC13599335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.