Evidence map›Paper›PMID 42393530›Full record

ArticleMolecular medicine (Cambridge, Mass.)2026

METTL3/YTHDC1 axis-mediated m

Yujia Zhao, Longjia Tang, Hongtian Zhang, Xu Liu, Haonan Zhang, Ying Zhao, Legao Chen, Xiaoting Chen, Xiaohong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yujia Zhao *Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Longjia Tang *Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Hongtian ZhangGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Xu LiuGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Haonan ZhangGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Ying ZhaoGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Legao ChenDepartment of Vascular Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Xiaoting ChenGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China.
Xiaohong WuGeriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P. R. China. drxhwu@njmu.edu.cn.

Funding

Medical and Health Science Program of Zhejiang Province WKJ-ZJ-26002National Natural Science Foundation of China 81970714the Joint Funds of Zhejiang Provincial Natural Science Foundation of China LHDMZ23H070001Zhejiang Province Health Innovative Talents Project 2021-CXRC07-01Zhejiang Province Science and Technology Plan Project 2021R52022
6 · The paper itself

Abstract

BACKGROUND AND

aimsEndothelial dysfunction is critical in diabetic angiopathy. While our previous study established role of FOXO1 in mediating advanced glycation end products (AGEs)-induced autophagic apoptosis in human aortic endothelial cells (HAECs), the potential mechanism of N6-methyladenosine (m

methodsRNA-m

resultsRNA m

conclusionsThe METTL3/YTHDC1 axis-mediated m

Indexed as

ApoptosisAtherosclerosisAutophagyEndothelial CellsForkhead Box Protein O1MethyltransferasesRNA Splicing FactorsAdenosineAnimalsEpitranscriptomeHumansMaleMiceMice, KnockoutNerve Tissue ProteinsRNA, MessengerAdenosineForkhead Box Protein O1FOXO1 protein, humanMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseNerve Tissue ProteinsN-methyladenosineRNA, MessengerRNA Splicing FactorsYTHDC1 protein, humanApoptosisAutophagyDiabetic atherosclerosisEndothelial cellsN6-methyladenosine

Identifiers

PMID42393530
PMCPMC13602580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.