ArticleMikrochimica acta2026
Augmenting in vitro cancer cell toxicity via reactive oxygen species burst and glucose depletion induced by C14-Cu/Pt bimetallic nanozyme cascade reaction.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
DNA-templated Cu/Pt nanoclusters (DNA-Cu/Pt NCs) were fabricated using four single-stranded oligonucleotides (C14, G14, A14, and T14) as the templates. Their oxidoreductase-like properties, including peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) activities, were systematically investigated for the first time. The results revealed that all as-prepared nanomaterials exhibited four distinct enzyme-like activities, and both DNA sequences and the molar ratio of precursor metal ions exerted significant impacts on their catalytic performance. When the molar ratio of precursor Cu (Ⅱ) to Pt (Ⅱ) was 10:4, C14-Cu/Pt NCs exhibited superior POD- and CAT-like activities, whereas A14-Cu/Pt NCs showed the strongest OXD-like catalytic performance. On the contrary, A14-Cu NCs possessed the highest SOD-like activity. All three NCs displayed uniform size distribution, and Pt(0)/Pt(Ⅱ) (for bimetallic NCs) as well as Cu(0)/Cu(Ⅰ)/Cu(II) species coexisted on the NC surface. Furthermore, both C14-Cu/Pt NCs and A14-Cu/Pt NCs exhibited excellent glutathione (GSH) oxidase (GSHOx)- and gluocose oxidase (GOx)-mimicking activities. Notably, compared to natural horseradish peroxidase, C14-Cu/Pt NCs exhibited 2.4- and 92.5-fold lower Michaelis constant (K
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