Evidence map›Paper›PMID 42393375›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2026

Developing a prioritized research agenda for necrotizing enterocolitis.

Ravi Mangal Patel, Allison T Rose, Stacey Neves, Rebeca Giacinto, Susan Perez, Jae Kim, Camilia R Martin, Misty Good, Toby Yanowitz, Jochen Profit and 14 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ravi Mangal PatelEmory University and Children's Healthcare of Atlanta, Atlanta, GA, USA. rmpatel@emory.edu.ORCID http://orcid.org/0000-0002-7444-5550
Allison T RoseEmory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8933-2295
Stacey NevesUniversity of California Davis, Davis, CA, USA.
Rebeca GiacintoUniversity of California Davis, Davis, CA, USA.
Susan PerezNEC Society, Davis, CA, USA.
Jae KimCincinnati Children's, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-6321-2594
Camilia R MartinWeill Cornell Medicine, New York, NY, USA.
Misty GoodUniversity of North Carolina, Chapel Hill, NC, USA.
Toby YanowitzUniversity of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3973-0559
Jochen ProfitStanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-3782-9248
Brian ScottolineOregon Health & Sciences University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-0207-9624
Troy A MarkelIndiana University School of Medicine, Indianapolis, IN, USA.
Marie SpruceNEC UK, Nottingham, UK.
Amy HairBaylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7570-0667
Mark UnderwoodUniversity of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-7453-5022
Jenny QuinnNEC Society, Davis, CA, USA.
Simone RositoNEC Society, Davis, CA, USA.ORCID http://orcid.org/0009-0009-5564-5950
Erin PryorNEC Society, Davis, CA, USA.
Lelis VernonNEC Society, Davis, CA, USA.ORCID http://orcid.org/0000-0003-0537-4733
Amena MebaneNEC Society, Davis, CA, USA.
Linseigh GreenNEC Society, Davis, CA, USA.
Erin UmbergerNEC Society, Davis, CA, USA.
Jennifer CanvasserNEC Society, Davis, CA, USA.
NEC Society Patient-Centered Outcomes Research Leadership Team

Funding

Patient-Centered Outcomes Research Institute (PCORI) EA 15158
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) research priorities informed by a broad group of stakeholders have not been previously determined.

methodsWe recruited 11 patient-families and 11 clinician-researchers to develop a prioritized research agenda from 11/19 to 8/22. We identified topics to prioritize through a systematic literature review, analysis of patient stories, and an open-ended survey, and prioritized these in a two-round Delphi process.

resultsWe identified and consolidated 157 potential topics from 1754 research articles, 236 patient-family stories, and 10 survey themes, focusing on patient-centered or comparative effectiveness research. The top 6 priorities were: (1) Medications and treatment to prevent NEC; (2) Human milk and lactation support; (3) Tools for diagnosing NEC; (4) Acute management of NEC; (5) Patient-family engagement; (6) Long-term gastrointestinal outcomes.

conclusionsThe top 6 research topics, identified collaboratively through patient-family and clinician-researcher partnerships, should be prioritized by scientists, administrators, funders, policymakers, and others to accelerate research meaningful to NEC stakeholders.

Indexed as

Biomedical ResearchEnterocolitis, NecrotizingDelphi TechniqueHumansInfant, NewbornInfant, PrematureMilk, Human

Identifiers

PMID42393375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.