Evidence map›Paper›PMID 42393279›Full record

ArticleMikrochimica acta2026

Ag-rich Ag-Au nanoshells based lateral flow immunoassay for rapid and sensitive detection of bovine viral diarrhea virus.

Yuxin Ding, Wenwen Zhang, Yusen Huang, Ruihua Zhang, Zilong Cheng, Yunfeng Long, He Zhu, Xinhuan Liu, Leilei Yang, Ting Yuan and 5 more

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuxin DingInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Wenwen ZhangInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Yusen HuangNanobiotechnology Laboratory, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China.
Ruihua ZhangBright Farming Co., Ltd, Shanghai, 201103, P.R. China.
Zilong ChengInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Yunfeng LongPlant and Food Inspection Center, Nanjing Customs, Nanjing, 210019, China.
He ZhuPlant and Food Inspection Center, Nanjing Customs, Nanjing, 210019, China.
Xinhuan LiuInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Leilei YangInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Ting YuanInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Dawei GuoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Qi ZhangCollege of Veterinary Medicine, Northwest A&F University, Yangling, 712100, China.
Zhixin FengInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Zhirui GuoNanobiotechnology Laboratory, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China. zhiruiguo@njmu.edu.cn.
Wenliang LiInstitute of Veterinary Medicine, Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture and Rural Affairs, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China. kfliwenliang@163.com.

Funding

Agricultural Science ,Technology Independent Innovation Fund of Ningxia Hui Autonomous Region NKYGZL-2026-03Key Research and Development Program of Jiangsu Province BE2022394Nanjing Science and Technology Development Foundation 202205066
6 · The paper itself

Abstract

Bovine viral diarrhea virus (BVDV) is a key member of the genus Pestivirus, which can cause persistent infections (PI) characterized by immunotolerance, leading to significant economic losses to the cattle industry globally. Among the detection methods for BVDV, conventional gold nanoparticles-based lateral flow immunoassay (Au NPs-based LFIA), which uses gold nanoparticles as signal reporters, often suffers from low sensitivity due to insufficient signal brightness. The development of more sensitive point-of-care testing (POCT) methods is urgently needed. In the present study, we developed a novel signal reporter based on Ag-rich Ag-Au nanoshells (AgR-Au NSs) featuring enhanced visual color brightness. The developed AgR-Au NSs-based LFIA enables one-step BVDV detection within 20 minutes. Under optimized conditions, the visual detection limit reached 1.95 × 10

Indexed as

Diarrhea Viruses, Bovine ViralGoldMetal NanoparticlesSilverAnimalsAntibodies, ViralCattleImmunoassayLimit of DetectionRapid Diagnostic TestsAntibodies, ViralGoldSilverAg-rich Ag-Au nanoshellsBovine viral diarrhea virusEnhanced visual color brightnessLateral flow immunoassayPoint-of-care testing

Identifiers

PMID42393279

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.