Evidence map›Paper›PMID 42393237›Full record

ArticleScientific reports2026

Continuous extracorporeal hyperoxygenation therapy reduces carbon monoxide half-life time in a carbon monoxide-poisoned pig model: a feasibility study.

A Fischbach, P C Schlanstein, M F Menne, C Hoffmann, C Lübke, H Lüken, S B Wiegand, S V Jansen, U Steinseifer, N B Steuer and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A FischbachDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany. afischbach@ukaachen.de.
P C SchlansteinCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
M F MenneCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
C HoffmannCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
C LübkeDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
H LükenDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
S B WiegandDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
S V JansenCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
U SteinseiferCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
N B SteuerCardiovascular Engineering, Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
R KoppDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon monoxide (CO) poisoning is a leading cause of toxic exposure-related morbidity and mortality worldwide. Although hyperbaric oxygen therapy increases CO elimination, its clinical use is limited by accessibility, side effects, and inconclusive long-term efficacy. We developed a cEHT system - a device for continuous extracorporeal hyperoxygenation therapy that enhances CO removal from blood without exposing patients to systemic hyperbaric conditions. The system was tested in vitro and in vivo in a porcine CO poisoning model. Carboxyhemoglobin (COHb) half-life, hemodynamics, hemolysis, and tissue hypoxia were evaluated. In vivo, the cEHT system significantly reduced COHb half-life by 53% compared to ventilation with 100% oxygen alone (27.0 ± 0.3 min vs. 57.6 ± 12.5 min; p = 0.01). Hemodynamic parameters, pulmonary artery pressure, and plasma-free Hb remained stable during treatment. Histological analyses showed reduced ischemic injury in heart and brain tissues in the cEHT group in contrast to the control group. The cEHT system enables effective and hemodynamically stable extracorporeal CO elimination. It may offer a promising therapy for CO poisoning when a pressure chamber is not promptly available. Further studies are needed to optimize system performance and assess clinical translation.

Indexed as

Carbon MonoxideCarbon Monoxide PoisoningHyperbaric OxygenationAnimalsCarboxyhemoglobinDisease Models, AnimalFeasibility StudiesFemaleHalf-LifeHemodynamicsOxygenSwineCarbon MonoxideCarboxyhemoglobinOxygenCarbon monoxideCarbon monoxide eliminationCarbon monoxide poisoningExtracorporeal membrane oxygenationHyperbaric oxygen therapy

Identifiers

PMID42393237
PMCPMC13328516

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.