Evidence map›Paper›PMID 42393218›Full record

ArticleCommunications biology2026

Choline-dependent methionine metabolism supports leukemia progression.

Nirmalya Saha, Lauren Lachowski, Franchesca Franzen, Sydney Alibeckoff, Victor Vitvitsky, Roshan Kumar, Melanie Hutchings, Malathi Kandarpa, Hsiangyu Hu, James Ropa and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nirmalya SahaDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA. nisaha@umich.edu.ORCID http://orcid.org/0000-0002-5624-8879
Lauren LachowskiDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0006-4127-7219
Franchesca FranzenDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Sydney AlibeckoffDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Victor VitvitskyDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Roshan KumarDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5372-8682
Melanie HutchingsDepartment of Nutrition and Food Science, Wayne State University, Detroit, MI, USA.
Malathi KandarpaDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0440-4964
Hsiangyu HuDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
James RopaIndiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-6120-1859
Marisa J L AitkenDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7937-531X
Mark Y ChiangDivision of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-2099-0956
Li ZhangDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9309-6141
Shannon A CartyDivision of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Moshe TalpazDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3361-3981
Smiti Vaid GuptaDepartment of Nutrition and Food Science, Wayne State University, Detroit, MI, USA.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8332-3275
Andrew G MunteanDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA. andrewmu@umich.edu.ORCID http://orcid.org/0000-0003-3034-0682

Funding

Sulfide Oxidation and SignalingR35GM130183 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUMA V BANERJEE · 2019 to 2026
$3.6M
The role for ER associated degradation (ERAD) in T cell homeostasis and memoryR01AI165533 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shannon A. Carty · 2023 to 2026
$2.2M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI165533NIAID NIH HHS R01 AI165533NIGMS NIH HHS R35 GM130183U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL136420U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM130183
6 · The paper itself

Abstract

Tumor cells must occupy and thrive in a competitive microenvironment marked by limited metabolites, including essential amino acids like methionine. Using a leukemia suppression model and CRISPR screening, we found that the choline transporter SLC44A1 is overexpressed in leukemia patients and impacts leukemogenesis. Choline is an important nutrient for membrane synthesis and less commonly contributes to the methionine cycle. A metabolic analysis demonstrated that metabolites of the methionine pathway are significantly elevated in leukemic cells. Surprisingly, dietary restriction of methionine accelerated leukemogenesis in vivo. Choline can serve as an alternative source for methionine via the enzymatic activity of CHDH and BHMT. Under restrictive methionine conditions, BHMT and CHDH are significantly upregulated. In vivo, BHMT and CHDH are necessary for leukemia progression where they utilize choline as an alternative source to satisfy increased methionine demand. This pathway represents a vulnerability in cancer cells that may be exploited for therapeutic intervention.

Indexed as

CholineLeukemiaMethionineAnimalsCell Line, TumorDisease ProgressionHumansMiceCholineMethionine

Identifiers

PMID42393218

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.