Evidence map›Paper›PMID 42393174›Full record

ArticleScientific reports2026

Cryopreservation alters contractile function of human induced pluripotent stem cell-derived cardiomyocytes.

Kathrin Kowalski, Benita Haß, Judith Montag, Joachim D Meißner, Jana Teske, Robert Zweigerdt, Theresia Kraft

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathrin KowalskiInstitute of Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany. kowalski.kathrin@mh-hannover.de.ORCID 0009-0004-1783-5896
Benita HaßInstitute of Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany.
Judith MontagInstitute of Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany.
Joachim D MeißnerInstitute of Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany.
Jana TeskeDepartment of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School (MHH), Hannover, Germany.
Robert ZweigerdtDepartment of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School (MHH), Hannover, Germany.
Theresia KraftInstitute of Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced protocols are available for efficient generation of large quantities of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Nevertheless, hiPSC-CMs show large batch to batch variations as well as fetal-like phenotype. Cryopreservation enables long-term storage of batches, leading to increased consistency and reproducibility of data while improving maturation. However, controversial data regarding comparability of fresh and cryopreserved hiPSC-CMs have been reported. Here, we compared fresh and cryopreserved hiPSC-CMs, demonstrating that both cryopreservation media (CryoStor

Indexed as

CryopreservationInduced Pluripotent Stem CellsMyocardial ContractionMyocytes, CardiacCell DifferentiationCells, CulturedHumansSarcomeresContraction parametersCryopreservationhiPSC-CMsLong-term culture

Identifiers

PMID42393174
PMCPMC13328489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.