Evidence map›Paper›PMID 42392958›Full record

ReviewTrends in molecular medicine2026

Clonal hematopoiesis in Alzheimer's brain: Protective, pathogenic, and context-dependent?

Hong Zhao, Katherine Y King, Stephen T Wong

Abstract readReview
In one paragraph

Review in Trends in molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hong ZhaoSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX, USA; School of Engineering Medicine, Texas A&M University, Houston, TX, USA; Department of Medicine, Houston Methodist Hospital and Weill Cornell Medicine, New York, NY, USA. Electronic address: hzhao@houstonmethodist.org.
Katherine Y KingDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Stephen T WongSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX, USA; School of Engineering Medicine, Texas A&M University, Houston, TX, USA; Department of Medicine, Houston Methodist Hospital and Weill Cornell Medicine, New York, NY, USA.

Funding

Systematic modeling and prediction of cell-type-specific and spatiotemporal crosstalk pathways in Alzheimer's DiseaseR01AG071496 · NIA · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KIM, DOO YEON, WONG, STEPHEN TC · 2021 to 2025
$4.0M
Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumorsR01CA238727 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WONG, STEPHEN TC, ZHAO, HONG · 2020 to 2024
$2.6M
The Contribution ofInfection to Preleukemic Clonal HematopoiesisR01HL136333 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.9M
NCI NIH HHS R01 CA238727NHLBI NIH HHS R01 HL136333NIA NIH HHS R01 AG071496
6 · The paper itself

Abstract

Clonal hematopoiesis is emerging as a surprising modifier of Alzheimer's disease. Recent findings suggest that mutant myeloid cells may enter or expand within the brain, adopting either inflammatory or reparative states. We propose that their effects depend on the mutation, timing, clone size, brain niche, and disease stage.

Indexed as

Alzheimer DiseaseBrainClonal HematopoiesisAnimalsHumansMicrogliaMutationMyeloid CellsAlzheimer’s diseaseclonal hematopoiesismicrogliamyeloid evolutionneuroinflammationsomatic mutations

Identifiers

PMID42392958
PMCPMC13352685

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.