Ultrasound-assisted deep eutectic solvent extraction of tyrosinase inhibitors from lotus seed peel powder.

Chengheng Zhang, Jin Liu, Jingjing Tan, Jiangtao Cai, Ying Long, Senwen Deng, Shiyin Guo, Changwei Liu

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Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Chengheng ZhangHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.

Jin LiuHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.

Jingjing TanHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.

Jiangtao CaiHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.

Ying LongHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.

Senwen DengHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China; Yuelushan Laboratory of Hunan Province, Changsha 410004, China. Electronic address: dswwzls@hnust.edu.cn.

Shiyin GuoHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China. Electronic address: gsy@hunau.edu.cn.

Changwei LiuHunan Engineering Research Center of Lotus Deep Processing and Nutritional Health Sciences, Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China; School of Resource & Environment and Safety Engineering, Hunan University of Science and Technology, Xiangtan 411201, China. Electronic address: lcvv@hnust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lotus seed peel powder (LSP), a major by-product of lotus seed processing, is rich in bioactive constituents but remains largely underutilized. Conventional aqueous and ethanolic extraction methods for LSP are constrained by low extraction efficiency and poor selectivity. In this study, an ultrasound-assisted deep eutectic solvent (DES) extraction (UADE) strategy was developed to recover tyrosinase inhibitors from LSP. UADE significantly enhanced flavonoid and polyphenol extraction compared with traditional methods. Among the tested DESs, the L-proline/lactic acid system exhibited the highest selectivity for tyrosinase inhibitors. Using response surface methodology, the optimal extraction conditions were determined as follows: Pro to LA 1:2, 20 % water, solid-to-liquid ratio 1:40 (w/v), 47 °C, 300 W, 70 min. Under these conditions, the tyrosinase inhibition rate reached 96.51 %, and the half-maximal inhibitory concentration (IC

Indexed as

Chemical FractionationDeep Eutectic SolventsEnzyme InhibitorsLotusMonophenol MonooxygenaseSeedsUltrasonic WavesMolecular Docking SimulationPowdersDeep Eutectic SolventsEnzyme InhibitorsMonophenol MonooxygenasePowdersDeep eutectic solventLotus seed peel powderTyrosinase InhibitorUltrasound-assisted extraction

Identifiers

PMID42391707

DOI10.1016/j.ultsonch.2026.107944

PMCPMC13355477

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