Evidence map›Paper›PMID 42391705›Full record

ArticleSeminars in arthritis and rheumatism2026

Autoantibody associations in patients with early diffuse cutaneous systemic sclerosis: the prospective registry of early systemic sclerosis.

Aradhna Agarwal, Dahlia Hassan, Suiyuan Huang, Flavia V Castelino, Shervin Assassi, Robyn T Domsic, Tracy M Frech, Jessica K Gordon, Faye N Hant, Monique E Hinchcliff and 5 more

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In one paragraph

Article in Seminars in arthritis and rheumatism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aradhna AgarwalColumbia University Irving Medical Center, New York, NY, USA.
Dahlia HassanHospital for Special Surgery, New York, NY, USA.
Suiyuan HuangUniversity of Michigan, Ann Arbor, MI, USA.
Flavia V CastelinoMassachusetts General Hospital, Boston, MA, USA.
Shervin AssassiUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Robyn T DomsicUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Tracy M FrechVanderbilt Medical Center, Nashville, TN, USA.
Jessica K GordonHospital for Special Surgery, New York, NY, USA.
Faye N HantMedical University of South Carolina, Charleston, SC, USA.
Monique E HinchcliffYale University, New Haven, CT, USA.
Ami A ShahJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Victoria K ShanmugamNational Institutes of Health, Bethesda, MD, USA.
Virginia D SteenGeorgetown University, Washington, DC, USA.
Dinesh KhannaUniversity of Michigan, Ann Arbor, MI, USA.
Elana J BernsteinColumbia University Irving Medical Center, New York, NY, USA. Electronic address: ejb2153@cumc.columbia.edu.

Funding

Vasculopathy and Systemic Sclerosis-Associated Interstitial Lung DiseaseR01HL164758 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Elana J. Bernstein · 2022 to 2026
$3.5M
Harnessing multivariate patient- and population-level disease trajectories to predict major clinical events in sclerodermaK24AR080217 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Ami Aalok Shah · 2022 to 2026
$847k
Screening Chest CT to Detect Interstitial Lung Disease in Systemic SclerosisK23AR075112 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERNSTEIN, ELANA · 2019 to 2023
$794k
Multidisciplinary Training in Molecular and Translational Rheumatology ResearchT32AR076953 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BATHON, JOAN MARIE, WINCHESTER, ROBERT J · 2021 to 2025
$742k
NHLBI NIH HHS R01 HL164758NIAMS NIH HHS K23 AR075112NIAMS NIH HHS K24 AR080217NIAMS NIH HHS T32 AR076953
6 · The paper itself

Abstract

objectiveAnti-RNA-polymerase-III (ARA) and anti-topoisomerase-I (ATA) autoantibodies are associated with diffuse cutaneous SSc (dcSSc). ARA is associated with rapidly progressive skin thickening, scleroderma renal crisis (SRC), and gastric antral vascular ectasia, while ATA is associated with severe interstitial lung disease (ILD). However, these associations were derived from heterogenous SSc cohorts. As SSc is now often diagnosed earlier, we aimed to ascertain whether these relationships hold true in early dcSSc and to examine autoantibody associations with organ involvement in early dcSSc.

methodsThe Prospective Registry of Early Systemic Sclerosis (PRESS) includes adults with dcSSc ≤2 years from the first non-Raynaud's phenomenon symptom who met 2013 ACR/EULAR classification criteria for SSc. Participants were enrolled at 12 U.S. academic centers and evaluated every 6 months. Those with dual-positivity were excluded. Differences across autoantibody groups were assessed using appropriate parametric and nonparametric tests.

resultsOf 303 enrolled, 233 participants were included (108 ARA+, 68 ATA+, 57 double-negative). Mean age was 51 years; 68% were female. Mean disease duration was 1.2 years. ATA+ participants had lower baseline FVC% predicted (76.0%vs 86.0% ARA+, p = 0.0011) and higher prevalence of ILD (69.6%vs 44.3% ARA+, p = 0.0029). ARA+ participants had higher baseline mRSS (25.0 vs 17.9 ATA+, p < 0.0001) and higher prevalence of SRC (14.4%vs 0.0% ATA+, p = 0.0024). Only the double-negative group had improvement in FVC% predicted over time (+1.39% per year, p = 0.03).

conclusionsAutoantibody-specific differences in organ involvement were evident early. The double-negative group uniquely showed improvement in lung function over time.

Indexed as

AutoantibodiesDNA Topoisomerases, Type IRNA Polymerase IIIScleroderma, DiffuseAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRegistriesAutoantibodiesDNA Topoisomerases, Type IRNA Polymerase IIIAnti–RNA polymerase III antibodiesAnti–topoisomerase I antibodiesAutoantibody subsetsDiffuse cutaneous systemic sclerosisEarly diseaseSystemic sclerosis

Identifiers

PMID42391705
PMCPMC13336313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.