Evidence map›Paper›PMID 42391385›Full record

ArticleScience (New York, N.Y.)2026

ILC2s regulate a fibroblast progenitor niche in the pancreas.

Thomas Yip, Julie Stockis, Charlotte Simpson, Erika E McCartney, Shwetha Raghunathan, Martha M Rangel-Sosa, Sydney N Hummel, Julia Moreno-Vicente, Gianmarco Raddi, Celine Garcia and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Thomas YipUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0009-0007-6287-3543
Julie StockisUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0003-4911-6891
Charlotte SimpsonUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0002-8410-7870
Erika E McCartneyUniversity of Toronto, Department of Immunology, Toronto, ON, Canada.ORCID 0000-0002-6354-0915
Shwetha RaghunathanUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.
Martha M Rangel-SosaUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0002-9074-9415
Sydney N HummelUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0003-2369-6795
Julia Moreno-VicenteUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0002-1740-9350
Gianmarco RaddiUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0003-1056-5403
Celine GarciaUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.
Rugile LinkuteUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.
Silvain PinaudUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0002-9541-3611
Maye F ChengUniversity of Toronto, Department of Immunology, Toronto, ON, Canada.
Lesley A HillDepartment of Cellular and Physiological Sciences and Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-6609-1935
T Michael UnderhillDepartment of Cellular and Physiological Sciences and Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-3048-9102
Hans-Reimer RodewaldDivision of Cellular Immunology, German Cancer Research Center; Heidelberg, Germany.ORCID 0000-0002-1452-3828
Christoph SchneiderDepartment of Physiology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0452-2960
Claus JørgensenUniversity of Manchester, Cancer Research UK Manchester Institute, Manchester, UK.ORCID 0000-0002-7841-943X
Andrew N J McKenzieMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-9757-2512
Sophie E ActonLaboratory for Molecular Cell Biology, University College London, London, UK.ORCID 0000-0003-2704-716X
Patrick SealeDepartment of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7119-1615
Menna R ClatworthyCambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge, Department of Medicine, Cambridge, UK.ORCID 0000-0002-3340-9828
Matthew B BuechlerUniversity of Toronto, Department of Immunology, Toronto, ON, Canada.ORCID 0000-0003-1902-622X
Timotheus Y F HalimUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID 0000-0001-9773-0023

Funding

Wellcome Trust
6 · The paper itself

Abstract

Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymphoid cells (ILC2s) as key regulators of fibroblast homeostasis in the pancreas. ILC2s colocalized with fibroblasts expressing the genes

Indexed as

FibroblastsImmunity, InnateLymphocytesPancreas, ExocrineStem Cell NicheAnimalsCell DifferentiationCollagenHomeostasisMaleMiceMice, Inbred C57BLPancreatic NeoplasmsPancreatitisStem CellsCollagencollagen XV, mouse

Identifiers

PMID42391385
PMCPMC7619465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.