ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2026
The Effect on Vitamin D Levels and VDR Gene Polymorphism on Clinical Outcomes in Asthma.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the relationship between vitamin D receptor gene polymorphism and vitamin D levels with asthma severity, control level, and exacerbation status in asthmatic patients. SUBJECTS AND
methodsOver a 6-month period, 162 patients diagnosed with asthma and 85 healthy volunteers were prospectively evaluated. Blood samples were analyzed for vitamin D receptor gene polymorphism by PCR and periostin by ELISA.
resultsAmong the study participants, 163 were females and 84 were males. The median value of vitamin D in the patient group was significantly lower at 13.95 (3.5-33) compared to 17 (6.1-39.9) in the control group (p = 0.003). A significant positive correlation was found between Vitamin D and Asthma Control Test (ACT), eosinophil count, peak expiratory flow (PEF, %) (r: 0.18-0.25, p < 0.05). When VDR gene polymorphism Fok1 and Apa1 alleles in the patient and control groups were examined, they were found to be similar (p > 0.05). However, when VDR gene polymorphism genotypes were analyzed in terms of vitamin D levels, no significant difference was found between Apa1 genotypes (CC, CT, TT). Regression analysis of variables, which are considered to influence vitamin D levels, showed that gender and PEF are independent determinants.
conclusionsIn our study, a significant relationship was found between vitamin D levels and asthma severity, asthma control level, and respiratory functions. However, no significant effect of VDR gene polymorphism was detected on the vitamin D levels and asthma.
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