Evidence map›Paper›PMID 42390953›Full record

ArticleBiochemistry2026

Differential Hydroxypyruvate Processing by

Stephanie Henriquez, Charles R Nosal, Lydia J Kramer, Eucolona M Toci, Sara A Trauth, Analisa M Lott, Caren L Freel Meyers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie HenriquezPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0003-3748-5358
Charles R NosalPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Lydia J KramerPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Eucolona M TociPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Sara A TrauthPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Analisa M LottPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Caren L Freel MeyersPhysiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0003-1458-0897

Funding

The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
Toward Understanding the Chemistry and Biology of Microbial DXP SynthaseR01GM143810 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Caren L. Freel Meyers · 2021 to 2026
$2.0M
NIGMS NIH HHS R01 GM143810NIGMS NIH HHS T32 GM080189
6 · The paper itself

Abstract

The thiamine diphosphate (ThDP)-dependent enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) converts pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) to the essential branchpoint metabolite, DXP. DXPS exhibits a ligand-gated mechanism where the predecarboxylation intermediate derived from pyruvate persists until d-GAP triggers decarboxylation. Together with its substrate/catalytic promiscuity and other features of multifunctionality, ligand gating on DXPS may poise this enzyme to catalyze alternate activities that aid in bacterial adaptation. We previously discovered alternative donors for

Indexed as

Bacterial ProteinsEscherichia coliPentosephosphatesPseudomonas aeruginosaPyruvatesTransferasesKineticsSubstrate SpecificityBacterial Proteinsdeoxyxylulose-5-phosphate synthasehydroxypyruvic acidPentosephosphatesPyruvatesTransferasesxylulose-5-phosphate

Identifiers

PMID42390953
PMCPMC13533544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.