Evidence map›Paper›PMID 42390805›Full record

ArticleSurgical endoscopy2026

Efficacy and safety of transoral incisionless fundoplication in non-obese and obese adults: a population-based cohort study from the United States.

Fouad Jaber, Saltenat Moghaddam Adames, Mohamed Jaber, Kinan Obiedat, Kalpesh Patel, Teminioluwa A Ajayi, Roy Tomas DaVee, Fares W Ayoub, Nirav Thosani, Wasseem Skef

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fouad JaberSection of Gastroenterology, Hepatology & Nutrition, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-4176-0332
Saltenat Moghaddam AdamesMargaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Mohamed JaberFaculty of Medicine, Rawalpindi Medical University, Rawalpindi, Punjab, Pakistan.
Kinan ObiedatDepartment of Medicine, Yale University, New Haven, CT, USA.
Kalpesh PatelSection of Gastroenterology, Hepatology & Nutrition, Baylor College of Medicine, Houston, TX, USA.
Teminioluwa A AjayiCenter for Interventional Gastroenterology at UTHealth, McGovern Medical School, Houston, TX, 77030, USA.
Roy Tomas DaVeeCenter for Interventional Gastroenterology at UTHealth, McGovern Medical School, Houston, TX, 77030, USA.
Fares W AyoubSection of Gastroenterology, Hepatology & Nutrition, Baylor College of Medicine, Houston, TX, USA.
Nirav ThosaniCenter for Interventional Gastroenterology at UTHealth, McGovern Medical School, Houston, TX, 77030, USA.
Wasseem SkefCenter for Interventional Gastroenterology at UTHealth, McGovern Medical School, Houston, TX, 77030, USA. wasseem.skef@uth.tmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransoral incisionless fundoplication (TIF) is relatively contraindicated in patients with a body mass index (BMI) > 35 kg/m

methodsWe conducted a retrospective cohort study using the TriNetX US Research Network, including data from 69 healthcare organizations through December 2024. Adults (≥ 18 years) with gastroesophageal reflux disease (GERD) who underwent TIF were identified using validated International Classification of Diseases, 10

resultsAfter propensity matching, 112 non-obese and 112 class I obese patients were included with similar baseline characteristics. Median follow-up exceeded 1,000 days in both groups. Postoperative PPI recidivism, esophagitis, surgical interventions, dysphagia and complications were similar. Notably, bloating was significantly lower in the obese group at 1 year (aOR 0.420; 95% CI 0.18-0.95) and maximum follow-up (aOR 0.446; 95% CI 0.21-0.97).

conclusionsTIF appears safe and effective for GERD in adults with class I obesity with comparable outcomes to non-obese patients.

Indexed as

FundoplicationGastroesophageal RefluxNatural Orifice Endoscopic SurgeryObesityAdultBody Mass IndexFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeUnited StatesBariatric surgeryGastroesophageal reflux disease (GERD)ObesityTransoral incisionless fundoplication

Identifiers

PMID42390805
PMCPMC13582028

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.