The utility of HALP, M-HALP, and the newly developed CANP scores in predicting prognosis of acute appendicitis.

We aimed to determine the effectiveness of the newly developed CANP score in determining prognosis by comparing it with the HALP score and the Modified HALP score in patients with complicated and uncomplicated acute appendicitis. After getting ethical approval and using the hospital data network, we retrospectively analyzed the demographic data, laboratory parameters, and pathology results of 80 female and 100 male patients aged from 15 to 95 years, who underwent surgery for acute appendicitis in the last two years. They were divided into patients with complicated and uncomplicated acute appendicitis. The HALP, Modified HALP, and CANP scores were compared by using statistical methods. According to the area under the ROC curve (AUC), the highest accuracy was found in the CANP score with an AUC of 0.980 (CI: 0.963-0.997), the sensitivity of 85.3%, and specificity of 97.3%. The AUC for M-HALP score was low as 0.322 (CI: 0.211-0.434), showing limited diagnostic value with a sensitivity of 26.5% and specificity of 58.9%. The AUC for the HALP score was the lowest, at 0.244 (CI: 0.161-0.328), with a sensitivity of 29.4% and specificity of 32.2%. Statistical significance was reported as p < 0.001. We showed that the CANP score, with a significantly higher AUC value and along with a higher sensitivity and specificity when compared to the HALP and M-HALP scores, was the most powerful discriminative parameter for predicting the complicated acute appendicitis, so it can be used as a more reliable scoring system in infectious diseases.