ArticleBioconjugate chemistry2026
Surfactant-Mediated Buchwald-Hartwig Coupling of Aliphatic Amines for the Synthesis of DNA-Encoded Libraries.
Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New and efficient chemical reactions with broad substrate applicability are needed to expand the diversity of DNA-encoded libraries (DELs), which are becoming established as a powerful technology for hit finding in medicinal chemistry. For reactions to be useful, they must be compatible with the DNA-tags and with the aqueous conditions used in DEL synthesis. One potential approach to address this requirement is the application of surfactant-mediated chemistry, which can lead to improved reaction efficiency. Our recent application of this technology to Buchwald-Hartwig aminations is very effective at coupling (hetero)aryl amines but performed less well for aliphatic substrates. This paper describes the development of an efficient, surfactant-promoted method of effecting on-DNA Buchwald-Hartwig aminations on DNA with aliphatic amines. This was developed through sequential optimization of the base, palladium ligand and the surfactant, for which Span 60 proved optimal. The applicability of the method is demonstrated across a broad substrate scope and its use in the synthesis of DELs is demonstrated by the synthesis of a prototype library.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.