ArticleDigestive diseases and sciences2026
Distinctive Endoscopic Ultrasound Features of Pancreatic Adenosquamous Carcinoma: A Propensity Score-Matched Analysis.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePancreatic adenosquamous carcinoma (PASC) is a rare and aggressive malignancy with poorer prognosis than pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify distinctive endoscopic ultrasound (EUS) features for pre-operative differentiation between PASC and PDAC.
methodsForty-six PASC patients and 683 PDAC patients were retrospectively enrolled. Propensity score matching (1:2) balanced age, sex, and tumor size. EUS characteristics were compared, and independent predictors were identified by multivariate logistic regression.
resultsPASC tumors were significantly larger than PDAC tumors at baseline (p < 0.001). After matching, multivariate analysis identified five independent predictors of PASC: higher serum albumin (OR = 1.256), hyperechoic foci (OR = 7.733), non-infiltrative growth pattern (INF C: OR = 0.163), and absence of pancreatic duct dilation (positive: OR = 0.021; unknown: 0.008) (all p < 0.05). The model demonstrated good discrimination with an AUC of 0.931 (95% CI 0.888-0.974). PASC more frequently exhibited hyperechoic foci (69.6% vs. 34.8%) and expansive growth, while PDAC typically showed infiltrative growth and duct dilation.
conclusionPASC demonstrates distinctive EUS features including hyperechoic foci, expansive growth pattern, and less frequent ductal obstruction compared with PDAC, which may facilitate pre-operative differentiation from PDAC.
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