Evidence map›Paper›PMID 42390701›Full record

ArticleMolecular biology reports2026

ATPR promotes differentiation in gastric cancer cells by endocan.

Jian Zhong, Qingya He, Xiaoli Jiang, Wenjing Zhou, Zihan Wang, Shengquan Zhang, Sumei Zhang

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jian ZhongDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Qingya HeDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Xiaoli JiangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Wenjing ZhouDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Zihan WangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Shengquan ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China. zhangshengquan@ahmu.edu.cn.
Sumei ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China. 379236778@qq.com.

Funding

Basic and Clinical Cooperative Research Promotion Program of Anhui Medical University 2023xkjT028Natural Science Foundation of Anhui Province 1708085MH212Natural Science Foundation of Anhui Province 2108085MH266University Natural Science Research Project of Anhui Province 2023AH050564University Natural Science Research Project of Anhui Province KJ2017A195
6 · The paper itself

Abstract

backgroundATPR (4-amino-2-trifluoromethyl-phenyl retinate), a derivative of ATRA (all-trans retinoic acid), exhibits potent anti-cancer activity by restoring the differentiation capacity of tumor cells. It has lower cytotoxicity compared to ATRA, making it a clinically valuable therapeutic agent. Endocan, encoded by ESM-1, a glycoprotein secreted by endothelial cells, is involved in multiple cellular proliferation processes. The high invasive capacity of gastric cancer is associated with abnormal differentiation. This study aims to investigate the mechanism by which ATPR modulates the differentiation capacity of gastric cancer cells and to elucidate the critical role of endocan in this process.

methodsGastric cancer cells (SGC-7901) were cultured and treated with a specific concentration of ATPR. We then performed Hoechst dye staining to assess cell viability, measured the activities of alkaline phosphatase (AKP) and lactate dehydrogenase (LDH) and examined endocan mRNA and protein levels. Subsequently, SGC-7901 cells cultured with ATPR were transfected with small interfering RNA (siRNA) targeting endocan. Changes in LDH and AKP activities were compared between the control group and the endocan knockdown group. RESULTS AND

conclusionsIn gastric cancer cells treated with ATPR, there was a significant reduction in the activities of LDH and AKP, accompanied by a marked increase in endocan expression at both mRNA and protein levels. In stable endocan-knockdown gastric cancer cells, the activities of LDH and AKP were significantly restored. These results suggest that ATPR promotes gastric cancer cell differentiation via endocan.

Indexed as

Cell DifferentiationNeoplasm ProteinsProteoglycansStomach NeoplasmsTretinoinAlkaline PhosphataseCell Line, TumorCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHumansRetinoidsRNA, Small Interfering4-amino-2-trifluoromethyl-phenyl retinateAlkaline PhosphataseESM1 protein, humanNeoplasm ProteinsProteoglycansRetinoidsRNA, Small InterferingTretinoin4-amino-2-trifluoromethyl-phenyl retinate (ATPR)Cell differentiationEndocanGastric cancer

Identifiers

PMID42390701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.