Electroacupuncture-modulated DHCR24 facilitates spinal cord injury recovery by attenuating apoptosis and neuroinflammation via the Wnt signaling pathway.

Chunlei Li, Yuan Li, Tongyan Liu, Yue Zong, Lingyun Zhou

Abstract read

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Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Chunlei LiDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Yuan LiOcular Motility Disorder Treatment and Rehabilitation Center, Department of Acupuncture, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Tongyan LiuOcular Motility Disorder Treatment and Rehabilitation Center, Department of Acupuncture, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Yue ZongDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Lingyun ZhouOcular Motility Disorder Treatment and Rehabilitation Center, Department of Acupuncture, the First Affiliated Hospital of Harbin Medical University, Harbin, China. 601419@hrbmu.edu.cn.ORCID 0000-0001-6659-3839

Funding

This research was funded by the National Natural Science Foundation of China No. 81674052 and 82074524

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a highly disabling condition affecting the central nervous system (CNS). Neuroinflammation and neuronal apoptosis are two critical factors in the pathological process of SCI. Although electroacupuncture (EA) has been reported to alleviate neuroinflammation in brain injury, the underlying molecular mechanism remains unclear. Transcriptome sequencing of spinal cord tissues was performed to identify potential key factors and pathways involved in EA post-SCI. DHCR24, a cholesterol synthesis regulator, was selected as a key candidate and DHCR24 was downregulated after SCI (log

Indexed as

ApoptosisElectroacupunctureNerve Tissue ProteinsNeuroinflammatory DiseasesOxidoreductases Acting on CH-CH Group DonorsRecovery of FunctionSpinal Cord InjuriesWnt Signaling PathwayAnimalsMicrogliaNeuronsRats, Sprague-DawleySpinal CordDHCR24 protein, ratNerve Tissue ProteinsOxidoreductases Acting on CH-CH Group Donors24-Dehydrocholesterol reductase (DHCR24)Electroacupuncture (EA)MicrogliaNeuroinflammationSpinal cord injury

Identifiers

PMID42390651

DOI10.1016/j.lfs.2020.118470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.