ArticleNeuroradiology2026
The blister sign on non-contrast CT for detection of blood blister-like aneurysms in acute subarachnoid hemorrhage.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeBlood blister-like aneurysms (BBLAs) are rare, fragile lesions associated with a high risk of early rebleeding, yet they are frequently occult on initial non-invasive imaging. Early identification is therefore critical. This study introduces a novel non-contrast CT (NCCT) marker - the blister sign -for early recognition of BBLAs in acute subarachnoid hemorrhage (SAH).
methodsWe conducted a retrospective multicenter cohort study across five tertiary neurovascular centers, including consecutive patients presenting with non-traumatic SAH in 2023. The blister sign was defined on NCCT as a rounded hyperdense juxtavascular focus with a central iso/hypodense core, located at a non-branching segment of the parent artery. Digital subtraction angiography (DSA) served as the reference standard. Two experienced neuroradiologists independently assessed the blister sign on baseline NCCT; discrepancies were resolved by consensus.
resultsAmong 335 included patients (mean age 55.1 years; 69.8% women), 13 BBLAs were confirmed. The blister sign was present in 16 patients (13 with BBLAs and 3 saccular aneurysms). Sensitivity and specificity for BBLA detection were 100% and 99.1%, respectively, with a positive predictive value of 81% and a negative predictive value of 100%. No BBLA was found in blister-sign negative patients. Inter-observer agreement was substantial (κ = 0.79; 95% CI: 0.63-0.95).
conclusionThe blister sign is an accurate and reproducible NCCT marker of BBLAs in acute SAH. Its identification may expedite targeted angiographic evaluation and intervention, whereas its absence may help exclude BBLA in SAH sine materia presentations. If validated prospectively, the blister sign could be incorporated into SAH diagnostic pathways.
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