ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Effect of ablation-zone diameter on whole-corneal higher-order aberrations after LASEK: a retrospective study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
purposeTo evaluate whether modest differences in programmed ablation-zone diameter (AZD) during LASEK affect postoperative whole-corneal higher-order aberrations (HOAs), with emphasis on spherical aberration (SA) and coma (CA).
methodsThis retrospective single-center observational study included 120 right eyes that underwent LASEK between January 2020 and June 2025. Eyes were grouped by programmed AZD: 5.75 mm (n = 41), 6.00 mm (n = 40), and 6.25 mm (n = 39). Corneal HOAs were measured by Pentacam at baseline, 1 and 3 months. Analyses included absolute changes, per-diopter normalization, SEQ-matched comparisons, and ablation-depth-matched sensitivity analyses.
resultsAll groups showed significant postoperative increases in total HOA, SA and CA at 3 months (P < 0.001). In unadjusted analyses, larger programmed AZDs exhibited smaller absolute increases in total HOA, SA and trefoil (P < 0.001). After per-diopter normalization, most zone-dependent differences were largely attenuated (P > 0.05 for most comparisons). SEQ-matched analyses showed that AZD enlargement reduced SA but tended to increase CA, without a uniform reduction in total HOA. After ablation-depth matching, larger programmed AZD was not associated with additional HOA induction.
conclusionsIn LASEK, larger programmed AZDs were associated with smaller unadjusted HOA and SA induction at 3 months; however, these associations were substantially influenced by baseline refractive magnitude and ablation depth. AZD selection should be individualized, balancing refractive correction, tissue removal, corneal safety, and centration strategy.
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