Evidence map›Paper›PMID 42390558›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Association between myosteatosis and bone mineral density in postmenopausal women.

Sung Jin Bae, Seung Hun Lee, Min Jung Lee, Eun Hee Kim, Ha Young Kim, Jaewon Choe, Hong Kyu Kim, Jung-Min Koh

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sung Jin Bae *Subdivision of Endocrinology and Metabolism, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Seung Hun Lee *Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
Min Jung LeeSubdivision of Endocrinology and Metabolism, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Eun Hee KimSubdivision of Endocrinology and Metabolism, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Ha Young KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.
Jaewon ChoeSubdivision of Endocrinology and Metabolism, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Hong Kyu KimSubdivision of Endocrinology and Metabolism, Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea. hkkim0801@amc.seoul.kr.ORCID http://orcid.org/0000-0002-7606-3521
Jung-Min KohDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea. jmkoh@amc.seoul.kr.

Funding

Ministry of Health and Welfare RS-2024-00507183
6 · The paper itself

Abstract

This study examined the association between abdominal muscle quality and bone mineral density (BMD) in 2021 postmenopausal women. A better muscle quality was associated with higher BMD and lower osteoporosis risk, independent of fat and muscle mass, highlighting the clinical relevance of muscle quality in bone health. PURPOSE: Loss of skeletal muscle and bone strength increases the risk of falls and fractures. The association between abdominal muscle quality-assessed by myosteatosis using computed tomography (CT)-and bone mineral density (BMD) remains unclear. We investigated this association in postmenopausal women who underwent abdominal CT during health check-ups.

methodsThe total abdominal muscle area (TAMA), visceral fat area (VFA), subcutaneous fat area (SFA), and skeletal muscle area (SMA) at the third lumbar vertebral level were measured. SMA was classified into normal attenuation muscle area (NAMA) and low attenuation muscle area (LAMA). The NAMA/TAMA index, which reflects the proportion of higher-quality muscle, was calculated.

resultsAmong 2021 women, 259 (12.8%) had osteoporosis. TAMA, SMA, NAMA (p < 0.001), and the NAMA/TAMA index (p = 0.012) were lower in the osteoporosis group. The prevalence of osteoporosis tended to decrease with increasing tertiles of the NAMA/TAMA index (15.3%, 12.2%, and 11.0%; p = 0.051). The prevalence of vertebral fractures decreased with increasing tertiles of the NAMA/TAMA index (p = 0.005). Lumbar spine, femoral neck, and total hip BMD increased significantly with higher NAMA/TAMA index tertiles after adjusting for confounders (p < 0.001, p = 0.011, and p < 0.001, respectively). The adjusted odds ratio (OR) for osteoporosis in the highest tertile was lower than in the lowest (OR = 0.58, 95% confidence interval = 0.38-0.87), even after adjusting for both abdominal fat and muscle area.

conclusionPostmenopausal women with higher-quality abdominal muscles exhibited higher BMD at all sites and a lower prevalence of osteoporosis, independent of abdominal adiposity and total muscle mass.

Indexed as

Bone mineral densityMyosteatosisOsteoporosisSkeletal muscle quality

Identifiers

PMID42390558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.