Evidence map›Paper›PMID 42390534›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Visual rating scales of atrophy differentiate sporadic behavioral variant frontotemporal dementia from primary psychiatric disorder: DIPPA study.

Giorgio Giulio Fumagalli, Chiara Fornari, Sterre C M de Boer, Chiara Fenoglio, Andrea Arighi, Lina Riedl, Ramon Landin-Romero, Sophie Matis, Ishana Rue, Zac Chatterton and 6 more

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giorgio Giulio FumagalliCenter for Mind/Brain Sciences (CIMeC), University of Trento, Corso Bettini 31, 38068, Rovereto, Italy. giorgio.fumagalli@unitn.it.
Chiara FornariCenter for Mind/Brain Sciences (CIMeC), University of Trento, Corso Bettini 31, 38068, Rovereto, Italy.
Sterre C M de BoerAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Chiara FenoglioOspedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Fondazione IRCSS Ca' Granda, Milan, Italy.
Andrea ArighiOspedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Fondazione IRCSS Ca' Granda, Milan, Italy.
Lina RiedlSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Ramon Landin-RomeroSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Sophie MatisSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Ishana RueDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Zac ChattertonBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Janine Diehl-SchmidSchool of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.
Glenda HallidayBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Olivier PiguetBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Daniela GalimbertiOspedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Fondazione IRCSS Ca' Granda, Milan, Italy.
Yolande PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic behavioral variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD) due to overlapping symptoms and lack of disease-specific biomarkers. This multicenter pilot study aimed to identify brain atrophy patterns using visual rating scales (VRS) that distinguish between groups, and to compare VRS performance with standard clinical assessment. Magnetic resonance images from bvFTD and PPD patients across five centers were retrospectively reviewed. One rater, blinded for the clinical diagnosis, applied eight VRS. Group differences were assessed, the most predictive scales were identified and combined into a composite score, and the predictivity compared. 297 bvFTD and 92 PPD patients were analysed. All VRS yielded higher atrophy in bvFTD than in PPD patients. The Orbitofrontal, the Anterior-Temporal, and the Fronto-Insula scales were the strongest discriminators, and their composite score outperformed any individual scale. VRS may provide useful diagnostic support for distinguishing bvFTD from PPD.

Indexed as

AtrophyBiomarkersDementiaFrontotemporal dementiaMagnetic resonance imagingPsychiatric disordersVisual rating scales

Identifiers

PMID42390534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.