ArticleBioprocess and biosystems engineering2026
Elicitors derived from endophytic fungus Acremonium sp. enhance triterpenoid and polysaccharide production in the submerged cultivation of the medicinal mushroom Inonotus obliquus.
Article in Bioprocess and biosystems engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triterpenoids and polysaccharides produced by Inonotus obliquus exhibit antitumor, antioxidant and hypoglycemic activities. Increasing the yields of triterpenoids and polysaccharides could effectively enhance the medicinal value of I. obliquus. In this study, the feasibility of improving the production of triterpenoids and polysaccharides by adding elicitors including cell wall debris (CW) and culture filtrate (CF) derived from endophytic fungus Acremonium sp. in the submerged cultivation of I. obliquus was investigated. The optimal concentrations and times for the addition of CW and CF were determined to be 60 µg/mL on day 3 and 10% v/v on day 1, respectively. The maximum total triterpenoid production of CW and CF groups increased by 19.38% and 49.81%, respectively, compared to the control. The maximum intracellular polysaccharide (IPS) production obtained with the CW and CF were 3.97 ± 0.24 and 4.95 ± 0.40 g/L, representing significant increases of 17.70% and 46.85% compared to the control. Additionally, the production of extracellular polysaccharides (EPS) was enhanced by 27.23% and 45.35% with the CW and CF, respectively, in comparison to the control. Furthermore, the transcription levels of the key genes involved in the biosynthesis of triterpenoids and polysaccharides were significantly upregulated in response to the elicitors. This study provides a novel approach for enhancing the bioactive metabolites production of medicinal basidiomycota by the elicitors derived from endophytes.
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