Evidence map›Paper›PMID 42390480›Full record

ArticleStatistical methods in medical research2026

Asymptotic online FWER control for dependent test statistics.

Vincent Jankovic, Lasse Fischer, Werner Brannath

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vincent JankovicCompetence Center for Clinical Trials Bremen, University of Bremen, Bremen, Germany.ORCID 0009-0005-3093-1134
Lasse FischerCompetence Center for Clinical Trials Bremen, University of Bremen, Bremen, Germany.ORCID 0000-0003-3380-0066
Werner BrannathCompetence Center for Clinical Trials Bremen, University of Bremen, Bremen, Germany.ORCID 0000-0002-8622-3904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In online multiple testing, an a priori unknown number of hypotheses are tested sequentially, that is, at each time point, a test decision for the current hypothesis has to be made using only the data available so far. Although many powerful test procedures have been developed for online error control in recent years, most of them are designed solely for independent or at most locally dependent test statistics. In this work, we provide a new framework for deriving online multiple test procedures that ensure asymptotical (with respect to the sample size) control of the familywise error rate, regardless of the dependence structure between test statistics. In this context, we give a few concrete examples of such test procedures and discuss their properties. Furthermore, we conduct a simulation study in which the type I error control of these test procedures is also confirmed for a finite sample size, and a gain in power is indicated.

Indexed as

Data Interpretation, StatisticalComputer SimulationHumansModels, StatisticalSample Sizeasymptoticsdependent test statisticsfamilywise error rateonline multiple testingplatform trials

Identifiers

PMID42390480
PMCPMC13478442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.