Trial reportMicrobiology spectrum2026
Benefits of three consecutive sputum inductions using nebulized racemic salbutamol versus hypertonic saline in smear-negative or sputum-scarce pulmonary tuberculosis patients: a prospective randomized, double-blind study.
Trial report in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although, sputum induction (SI) with hypertonic saline increases the diagnostic yield for suspected pulmonary tuberculosis (PTB) in patients with smear-negative microscopy, but, it carries adverse effects (AEs), particularly bronchospasm. This study assessed and compared the diagnostic yields and safety profiles of three consecutive SI procedures using nebulized salbutamol vs conventional 3% sodium chloride (NaCl) in patients with suspected PTB and initially negative sputum smears. A randomized, double-blind study was conducted at Songklanagarind Hospital, Thailand, between 2016 and 2019. Three hundred forty-five adults with suspected smear-negative or sputum-scarce PTB were randomized to undergo 3 consecutive days of SI with either nebulized salbutamol ( IMPORTANCE: Delays in diagnosing pulmonary tuberculosis or initiating treatment without bacteriological confirmation increase mortality, often because of inadequate sputum samples or negative acid-fast bacilli smears from self-expectoration. Sputum induction with hypertonic saline can improve diagnostic yield in patients with scanty sputum or smear-negative disease, but it is associated with adverse effects-particularly bronchospasm-which may require stopping the procedure. We demonstrated that three consecutive sputum inductions using nebulized racemic salbutamol produced significantly higher overall diagnostic yields by acid-fast bacilli smear and
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.