Evidence map›Paper›PMID 42390090›Full record

ArticleMicrobiology spectrum2026

Third-generation cephalosporin-induced L-form transition in

Sanjib Das, Arindam Mukherjee, Prolay Halder, Soumalya Banerjee, Supriya Mandal, Nivedita Roy, Ashis Debnath, Sreejani Banerjee, Manjistha Manna, Upama Mandal and 6 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sanjib DasDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Arindam MukherjeeDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Prolay HalderDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Soumalya BanerjeeDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Supriya MandalDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Nivedita RoyDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Ashis DebnathDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Sreejani BanerjeeDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Manjistha MannaDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Upama MandalDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Jiro MitobeDepartment of Bacteriology, National Institute of Infectious Diseases (NIID), Tokyo, Japan.
Jeffrey H WitheyDepartment of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, Michigan, USA.ORCID 0000-0001-6856-5604
Asish Kumar MukhopadhyayDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.ORCID 0000-0002-5638-4520
Santasabuj DasDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.
Debaki Ranjan HowladerDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.ORCID 0000-0002-3170-9851
Hemanta KoleyDivision of Bacteriology, ICMR-National Institute for Research in Bacterial Infections, Beliaghata, Kolkata, India.ORCID 0000-0003-1379-9563

Funding

DBT, India DBT-RRFICMR-National Institute for Research in Bacterial Infections, Kolkata ICMR-NIRBINational Institute of Infectious Diseases, Japan NIID-4UGC, India 231620010720UGC, India 3363/CSIR-UGC
6 · The paper itself

Abstract

Shigellosis remains a major global health burden, and the increasing prevalence of multidrug-resistant (MDR) IMPORTANCE: Our research provides critical insight into the challenge of antibiotic treatment failure in shigellosis. By integrating experimental validation of reversible L-form transitions with mathematical modeling, we uncover a crucial virulence-survival trade-off. We show that multidrug-resistant

Indexed as

Anti-Bacterial AgentsDysentery, BacillaryPersistent InfectionShigella sonneiThird Generation CephalosporinsAnimalsCeftriaxoneDisease Models, AnimalDrug Resistance, Multiple, BacterialFemaleGuinea PigsHumansMacrophagesMiceVirulenceAnti-Bacterial AgentsCeftriaxoneThird Generation Cephalosporinsanimal modelsceftriaxonechronic infectionL-form bacteriaShigella sonnei

Identifiers

PMID42390090
PMCPMC13436260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.