ArticleMicrobiology spectrum2026
The two-component regulator CvsR has a small core regulon
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pattern-triggered immunity (PTI) provides broad-spectrum protection in plants by activating defense responses upon perception of conserved microbial signatures such as bacterial flagellin. IMPORTANCE: Pattern-triggered immunity (PTI) provides broad-spectrum disease resistance in plants by recognizing conserved microbial patterns such as bacterial flagellin. Activation of PTI alters the environment that pathogens encounter during infection, yet how bacteria respond to these immune-imposed conditions at the molecular level remains poorly understood. In this study, we profile the bacterial transcriptome directly in planta during infection with RNA-seq, providing a detailed view of pathogen responses under immune pressure. We focus on the previously identified two-component regulator CvsR and show that, despite widespread transcriptional changes induced by PTI, CvsR directly controls only a small core set of genes in planta. Instead, most bacterial transcriptional shifts reflect indirect responses to the immune-modified host environment. By capturing pathogen gene expression during infection, this work clarifies how plant immunity constrains bacterial physiology and provides insight that can inform sustainable strategies for crop protection.
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